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Literature summary for 6.5.1.1 extracted from

  • Petermann, E.; Keil, C.; Oei, S.L.
    Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER (2006), DNA Repair, 5, 544-555.
    View publication on PubMed
Search for more literature for 6.5.1.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens damaged DNA bases are repaired by base excision repair which can proceed via two pathways: short patch and long patch base excision repair. Inhibition of long patch base excision repair is mediated by the ligation activity of Lig III. Lowering the levels of XRCC1 and Lig III in HeLa cells decreases cellular repair capacity, but substantially increases Pol beta-dependent strand displacement DNA synthesis AMP + diphosphate + (deoxyribonucleotide)n+m
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m damaged DNA bases are repaired by base excision repair which can proceed via two pathways: short patch and long patch base excision repair. Inhibition of long patch base excision repair is mediated by the ligation activity of Lig III. Lowering the levels of XRCC1 and Lig III in HeLa cells decreases cellular repair capacity, but substantially increases Pol beta-dependent strand displacement DNA synthesis Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
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 ?

Synonyms

Synonyms Comment Organism
DNA ligase III
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 Homo sapiens
Lig III
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 Homo sapiens