Literature summary for 6.5.1.1 extracted from

Kysela, B.; Doherty, A.J.; Chovanec, M.; Stiff, T.; Ameer-Beg, S.M.; Vojnovic, B.; Girard, P.M.; Jeggo, P.A.
Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule (2003), J. Biol. Chem., 278, 22466-22474.

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Cloned(Commentary)

Cloned (Comment)	Organism
coexpression of DNA ligase IV-XRCC4 complex in Sf9 insect cells	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	Homo sapiens	DNA ligase IV-XRCC4 complex functions in DNA non-homologous-end joining, the main pathwy for double-strand repair in mammalian cells	AMP + diphosphate + (deoxyribonucleotide)m+n	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant DNA ligase IV-XRCC4 complex, metal-chelate Talon affinity resin, Mono Q	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	ligation activity of DNA ligase IV-XRCC4 complex depends upon substrate length, efficient ligation of a 445 bp substrate, little ligation of a 53 bp substrate	Homo sapiens	AMP + diphosphate + (deoxyribonucleotide)m+n	-	?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	DNA ligase IV-XRCC4 complex functions in DNA non-homologous-end joining, the main pathwy for double-strand repair in mammalian cells	Homo sapiens	AMP + diphosphate + (deoxyribonucleotide)m+n	-	?

Synonyms

Synonyms	Comment	Organism
DNA ligase IV	-	Homo sapiens

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Release 2023.1 (January 2023)