Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.4.1.4 extracted from

  • Mock, D.M.
    Marginal biotin deficiency is common in normal human pregnancy and is highly teratogenic in mice (2009), J. Nutr., 139, 154-157.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.4.1.4

Activating Compound

Activating Compound Comment Organism Structure
biotin dependent on Mus musculus
biotin dependent on Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 3-methylcrotonoyl-CoA + HCO3- Mus musculus
-
 ADP + phosphate + 3-methylglutaconyl-CoA
-
 ?
ATP + 3-methylcrotonoyl-CoA + HCO3- Homo sapiens
-
 ADP + phosphate + 3-methylglutaconyl-CoA
-
 ?
additional information Homo sapiens induced marginal biotin deficiency increases urinary excretion of 3-hydroxyisovaleric acid caused by decreased activity of the biotin-dependent enzyme beta-methylcrotonyl-CoA carboxylase, and decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase in peripheral blood lymphocytes, overview. Relation of biotin deficiency during pregnancy to teratogenesis, biotin deficiency does cause human birth defects, overview ?
-
 ?
additional information Mus musculus induced marginal biotin deficiency increases urinary excretion of 3-hydroxyisovaleric acid caused by decreased activity of the biotin-dependent enzyme beta-methylcrotonyl-CoA carboxylase, and decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase in peripheral blood lymphocytes, overview. Relation of biotin deficiency during pregnancy to teratogenesis, in mice a marginal degree of biotin deficiency in the dam causes a severe degree of deficiency in the fetus, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 pregnant women
-
Mus musculus
-
 pregnant mice
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte from peripheral blood Mus musculus
-
lymphocyte from peripheral blood Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-methylcrotonoyl-CoA + HCO3-
-
 Mus musculus ADP + phosphate + 3-methylglutaconyl-CoA
-
 ?
ATP + 3-methylcrotonoyl-CoA + HCO3-
-
 Homo sapiens ADP + phosphate + 3-methylglutaconyl-CoA
-
 ?
additional information induced marginal biotin deficiency increases urinary excretion of 3-hydroxyisovaleric acid caused by decreased activity of the biotin-dependent enzyme beta-methylcrotonyl-CoA carboxylase, and decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase in peripheral blood lymphocytes, overview. Relation of biotin deficiency during pregnancy to teratogenesis, biotin deficiency does cause human birth defects, overview Homo sapiens ?
-
 ?
additional information induced marginal biotin deficiency increases urinary excretion of 3-hydroxyisovaleric acid caused by decreased activity of the biotin-dependent enzyme beta-methylcrotonyl-CoA carboxylase, and decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase in peripheral blood lymphocytes, overview. Relation of biotin deficiency during pregnancy to teratogenesis, in mice a marginal degree of biotin deficiency in the dam causes a severe degree of deficiency in the fetus, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
beta-methylcrotonyl-CoA carboxylase
-
 Mus musculus
beta-methylcrotonyl-CoA carboxylase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Homo sapiens