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Literature summary for 6.4.1.4 extracted from
- Kinetic characterization of mutations found in propionic acidemia and methylcrotonylglycinuria: Evidence for cooperativity in biotin carboxylase (2004), J. Biol. Chem., 279, 15772-15778.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| M169K | mutant with lack of carboxylation activity | Escherichia coli |
| R338Q | mutant with lack of carboxylation activity | Escherichia coli |
| R338S | mutant with lack of carboxylation activity | Escherichia coli |
| R385S | human mutant leading to methylcrotonylglycinuria | Escherichia coli |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.081 | - |
ATP | - |
Escherichia coli |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | Escherichia coli | - |
ADP + malonyl-CoA + phosphate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | - |
Escherichia coli | ADP + malonyl-CoA + phosphate | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | alphabeta | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MCC | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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