Literature summary for 6.4.1.4 extracted from

Wiedmann, S.; Eudy, J.D.; Zempleni, J.
Biotin supplementation increases expression of genes encoding interferon-gamma, interleukin-1beta, and 3-methylcrotonyl-CoA carboxylase, and decreases expression of the gene encoding interleukin-4 in human peripheral blood mononuclear cells (2003), J. Nutr., 133, 716-719.

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Cloned(Commentary)

Cloned (Comment)	Organism
reverse transcriptase PCR	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 3-methylcrotonyl-CoA + HCO3-	Homo sapiens	catalyzes essential steps in the metabolism of amino acids	ADP + phosphate + 3-methylglutaconyl-CoA	-	ir

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human, healthy caucasian adults	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 3-methylcrotonyl-CoA + HCO3-	-	Homo sapiens	ADP + phosphate + 3-methylglutaconyl-CoA	-	ir
ATP + 3-methylcrotonyl-CoA + HCO3-	catalyzes essential steps in the metabolism of amino acids	Homo sapiens	ADP + phosphate + 3-methylglutaconyl-CoA	-	ir

Cofactor

Cofactor	Comment	Organism	Structure
biotin	plays a role in regualtion of gene expression in addition to its role as a covalently bound group, biotin supplementation causes increase expression of the gene encoding 3-methylcrotonyl-CoA carboxylase alpha chain	Homo sapiens

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Release 2023.1 (January 2023)