Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.4.1.3 extracted from

  • Ballhausen, D.; Mittaz, L.; Boulat, O.; Bonafe, L.; Braissant, O.
    Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain (2009), Neuroscience, 164, 578-587.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
SDS-PAGE, Western blot analysis Rattus norvegicus
72000
-
Western blot analysis, PCCalpha in the adult brain and liver Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P14882
-
-
Rattus norvegicus P14882 Sprague–Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
brain in all regions of the adult rat brain Rattus norvegicus
-
brown adipose tissue
-
Rattus norvegicus
-
brown adipose tissue embryo, high level Rattus norvegicus
-
central nervous system adult, PCC together with methylmalonyl-CoA mutase and in whole rat embryonic central nervous system, both at E15.5 and E18.5 Rattus norvegicus
-
central nervous system PCCalpha is present in all regions of the central nervous system. PCCalpha is present in the whole embryonic central nervous system, both at E15.5 and E18.5, predominantely in the periventricular zones of telencephalon, midbrain and rhombencephalon Rattus norvegicus
-
cerebellum adult, highest level, Purkinje and granular layers Rattus norvegicus
-
cerebellum pons, medulla and the Purkinje and granular layers Rattus norvegicus
-
choroid plexus
-
Rattus norvegicus
-
choroid plexus adult and embryo Rattus norvegicus
-
embryo
-
Rattus norvegicus
-
embryo in embryos (E15.5 and E18.5), PCCalpha shows a much higher expression level in the entire central nervous system than in the liver Rattus norvegicus
-
hippocampus
-
Rattus norvegicus
-
hippocampus adult, highest level Rattus norvegicus
-
hypothalamic nucleus
-
Rattus norvegicus
-
hypothalamic nucleus adult, highest level Rattus norvegicus
-
liver in embryos (E15.5 and E18.5), PCCalpha shows a much higher expression level in the entire central nervous system than in the liver Rattus norvegicus
-
liver low levels in the E15.5 embryonic liver Rattus norvegicus
-
midbrain adult, highest level, such as the red nucleus and substantia nigra, as well as pons and medulla, and in embryo Rattus norvegicus
-
midbrain red nucleus and substantia nigra Rattus norvegicus
-
additional information in adult, absent from astrocytes, oligodendrocytes and microcapillary endothelial cells (blood-brain barrier). Present in rhombencephalon of embryos Rattus norvegicus
-
additional information PCCalpha is present in choroid plexus epithelium, is absent from astrocytes and oligodendrocytes and in microcapillary endothelial cells (blood– brain barrier) Rattus norvegicus
-
neocortex
-
Rattus norvegicus
-
neocortex adult, highest level Rattus norvegicus
-
neuron adult, PCC together with methylmalonyl-CoA mutase, basal ganglia Rattus norvegicus
-
neuron both, methylmalonyl-CoA mutase and PCCalpha enzymes are co-expressed in neurons. PCCalpha is present in neurons of basal ganglia Rattus norvegicus
-
spinal cord
-
Rattus norvegicus
-
spinal cord embryo Rattus norvegicus
-
telencephalon embryo, in the periventricular zones Rattus norvegicus
-
thalamic nucleus adult, highest level Rattus norvegicus
-
thalamus
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
PCC
-
Rattus norvegicus
Propionyl-CoA carboxylase
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus in rat embryos (E15.5 and E18.5), methylmalonyl-CoA mutase and PCC show a much higher expression level in the entire central nervous system than in the liver up

General Information

General Information Comment Organism
metabolism methylmalonyl-CoA mutase and PCC are key enzmyes in the catabolic pathway of propionate metabolism in the developing and adult rat central nervous system Rattus norvegicus