Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
72000 | - |
SDS-PAGE, Western blot analysis | Rattus norvegicus |
72000 | - |
Western blot analysis, PCCalpha in the adult brain and liver | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P14882 | - |
- |
Rattus norvegicus | P14882 | SpragueDawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
brain | in all regions of the adult rat brain | Rattus norvegicus | - |
brown adipose tissue | - |
Rattus norvegicus | - |
brown adipose tissue | embryo, high level | Rattus norvegicus | - |
central nervous system | adult, PCC together with methylmalonyl-CoA mutase and in whole rat embryonic central nervous system, both at E15.5 and E18.5 | Rattus norvegicus | - |
central nervous system | PCCalpha is present in all regions of the central nervous system. PCCalpha is present in the whole embryonic central nervous system, both at E15.5 and E18.5, predominantely in the periventricular zones of telencephalon, midbrain and rhombencephalon | Rattus norvegicus | - |
cerebellum | adult, highest level, Purkinje and granular layers | Rattus norvegicus | - |
cerebellum | pons, medulla and the Purkinje and granular layers | Rattus norvegicus | - |
choroid plexus | - |
Rattus norvegicus | - |
choroid plexus | adult and embryo | Rattus norvegicus | - |
embryo | - |
Rattus norvegicus | - |
embryo | in embryos (E15.5 and E18.5), PCCalpha shows a much higher expression level in the entire central nervous system than in the liver | Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
hippocampus | adult, highest level | Rattus norvegicus | - |
hypothalamic nucleus | - |
Rattus norvegicus | - |
hypothalamic nucleus | adult, highest level | Rattus norvegicus | - |
liver | in embryos (E15.5 and E18.5), PCCalpha shows a much higher expression level in the entire central nervous system than in the liver | Rattus norvegicus | - |
liver | low levels in the E15.5 embryonic liver | Rattus norvegicus | - |
midbrain | adult, highest level, such as the red nucleus and substantia nigra, as well as pons and medulla, and in embryo | Rattus norvegicus | - |
midbrain | red nucleus and substantia nigra | Rattus norvegicus | - |
additional information | in adult, absent from astrocytes, oligodendrocytes and microcapillary endothelial cells (blood-brain barrier). Present in rhombencephalon of embryos | Rattus norvegicus | - |
additional information | PCCalpha is present in choroid plexus epithelium, is absent from astrocytes and oligodendrocytes and in microcapillary endothelial cells (blood brain barrier) | Rattus norvegicus | - |
neocortex | - |
Rattus norvegicus | - |
neocortex | adult, highest level | Rattus norvegicus | - |
neuron | adult, PCC together with methylmalonyl-CoA mutase, basal ganglia | Rattus norvegicus | - |
neuron | both, methylmalonyl-CoA mutase and PCCalpha enzymes are co-expressed in neurons. PCCalpha is present in neurons of basal ganglia | Rattus norvegicus | - |
spinal cord | - |
Rattus norvegicus | - |
spinal cord | embryo | Rattus norvegicus | - |
telencephalon | embryo, in the periventricular zones | Rattus norvegicus | - |
thalamic nucleus | adult, highest level | Rattus norvegicus | - |
thalamus | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
PCC | - |
Rattus norvegicus |
Propionyl-CoA carboxylase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | in rat embryos (E15.5 and E18.5), methylmalonyl-CoA mutase and PCC show a much higher expression level in the entire central nervous system than in the liver | up |
General Information | Comment | Organism |
---|---|---|
metabolism | methylmalonyl-CoA mutase and PCC are key enzmyes in the catabolic pathway of propionate metabolism in the developing and adult rat central nervous system | Rattus norvegicus |