BRENDA - Enzyme Database show
show all sequences of 6.4.1.3

Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain

Ballhausen, D.; Mittaz, L.; Boulat, O.; Bonafe, L.; Braissant, O.; Neuroscience 164, 578-587 (2009)

Data extracted from this reference:

Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
72000
-
SDS-PAGE, Western blot analysis; Western blot analysis, PCCalpha in the adult brain and liver
Rattus norvegicus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
P14882
; Sprague–Dawley rats
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
; in all regions of the adult rat brain
Rattus norvegicus
-
brown adipose tissue
; embryo, high level
Rattus norvegicus
-
central nervous system
adult, PCC together with methylmalonyl-CoA mutase and in whole rat embryonic central nervous system, both at E15.5 and E18.5; PCCalpha is present in all regions of the central nervous system. PCCalpha is present in the whole embryonic central nervous system, both at E15.5 and E18.5, predominantely in the periventricular zones of telencephalon, midbrain and rhombencephalon
Rattus norvegicus
-
cerebellum
adult, highest level, Purkinje and granular layers; pons, medulla and the Purkinje and granular layers
Rattus norvegicus
-
choroid plexus
; adult and embryo
Rattus norvegicus
-
embryo
; in embryos (E15.5 and E18.5), PCCalpha shows a much higher expression level in the entire central nervous system than in the liver
Rattus norvegicus
-
hippocampus
; adult, highest level
Rattus norvegicus
-
hypothalamic nucleus
; adult, highest level
Rattus norvegicus
-
liver
in embryos (E15.5 and E18.5), PCCalpha shows a much higher expression level in the entire central nervous system than in the liver; low levels in the E15.5 embryonic liver
Rattus norvegicus
-
midbrain
adult, highest level, such as the red nucleus and substantia nigra, as well as pons and medulla, and in embryo; red nucleus and substantia nigra
Rattus norvegicus
-
additional information
in adult, absent from astrocytes, oligodendrocytes and microcapillary endothelial cells (blood-brain barrier). Present in rhombencephalon of embryos; PCCalpha is present in choroid plexus epithelium, is absent from astrocytes and oligodendrocytes and in microcapillary endothelial cells (blood– brain barrier)
Rattus norvegicus
-
neocortex
; adult, highest level
Rattus norvegicus
-
neuron
adult, PCC together with methylmalonyl-CoA mutase, basal ganglia; both, methylmalonyl-CoA mutase and PCCalpha enzymes are co-expressed in neurons. PCCalpha is present in neurons of basal ganglia
Rattus norvegicus
-
spinal cord
; embryo
Rattus norvegicus
-
telencephalon
embryo, in the periventricular zones
Rattus norvegicus
-
thalamic nucleus
adult, highest level
Rattus norvegicus
-
thalamus
-
Rattus norvegicus
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
72000
-
SDS-PAGE, Western blot analysis; Western blot analysis, PCCalpha in the adult brain and liver
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
; in all regions of the adult rat brain
Rattus norvegicus
-
brown adipose tissue
; embryo, high level
Rattus norvegicus
-
central nervous system
adult, PCC together with methylmalonyl-CoA mutase and in whole rat embryonic central nervous system, both at E15.5 and E18.5; PCCalpha is present in all regions of the central nervous system. PCCalpha is present in the whole embryonic central nervous system, both at E15.5 and E18.5, predominantely in the periventricular zones of telencephalon, midbrain and rhombencephalon
Rattus norvegicus
-
cerebellum
adult, highest level, Purkinje and granular layers; pons, medulla and the Purkinje and granular layers
Rattus norvegicus
-
choroid plexus
; adult and embryo
Rattus norvegicus
-
embryo
; in embryos (E15.5 and E18.5), PCCalpha shows a much higher expression level in the entire central nervous system than in the liver
Rattus norvegicus
-
hippocampus
; adult, highest level
Rattus norvegicus
-
hypothalamic nucleus
; adult, highest level
Rattus norvegicus
-
liver
in embryos (E15.5 and E18.5), PCCalpha shows a much higher expression level in the entire central nervous system than in the liver; low levels in the E15.5 embryonic liver
Rattus norvegicus
-
midbrain
adult, highest level, such as the red nucleus and substantia nigra, as well as pons and medulla, and in embryo; red nucleus and substantia nigra
Rattus norvegicus
-
additional information
in adult, absent from astrocytes, oligodendrocytes and microcapillary endothelial cells (blood-brain barrier). Present in rhombencephalon of embryos; PCCalpha is present in choroid plexus epithelium, is absent from astrocytes and oligodendrocytes and in microcapillary endothelial cells (blood– brain barrier)
Rattus norvegicus
-
neocortex
; adult, highest level
Rattus norvegicus
-
neuron
adult, PCC together with methylmalonyl-CoA mutase, basal ganglia; both, methylmalonyl-CoA mutase and PCCalpha enzymes are co-expressed in neurons. PCCalpha is present in neurons of basal ganglia
Rattus norvegicus
-
spinal cord
; embryo
Rattus norvegicus
-
telencephalon
embryo, in the periventricular zones
Rattus norvegicus
-
thalamic nucleus
adult, highest level
Rattus norvegicus
-
thalamus
-
Rattus norvegicus
-
Expression
Organism
Commentary
Expression
Rattus norvegicus
in rat embryos (E15.5 and E18.5), methylmalonyl-CoA mutase and PCC show a much higher expression level in the entire central nervous system than in the liver
up
General Information
General Information
Commentary
Organism
metabolism
methylmalonyl-CoA mutase and PCC are key enzmyes in the catabolic pathway of propionate metabolism in the developing and adult rat central nervous system
Rattus norvegicus
General Information (protein specific)
General Information
Commentary
Organism
metabolism
methylmalonyl-CoA mutase and PCC are key enzmyes in the catabolic pathway of propionate metabolism in the developing and adult rat central nervous system
Rattus norvegicus
Expression (protein specific)
Organism
Commentary
Expression
Rattus norvegicus
in rat embryos (E15.5 and E18.5), methylmalonyl-CoA mutase and PCC show a much higher expression level in the entire central nervous system than in the liver
up
Other publictions for EC 6.4.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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-
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1
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44
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Rattus norvegicus
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2009
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1
1
1
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Homo sapiens
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13
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690723
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369
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671196
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Homo sapiens
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84
384-388
2006
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679922
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Streptomyces coelicolor
FEMS Yeast Res.
6
40-47
2006
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661263
Rodriguez-Pombo
Towards a model to explain the ...
Homo sapiens
Biochim. Biophys. Acta
1740
489-498
2005
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8
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8
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662392
Jiang
Characterization of four varia ...
Homo sapiens
J. Biol. Chem.
280
27719-27727
2005
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1
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5
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1
1
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4
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661098
Diacovich
Crystal structure of the beta- ...
Streptomyces coelicolor
Biochemistry
43
14027-14036
2004
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1
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2
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1
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1
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662786
Dunn
Biochemical characterization o ...
Agrobacterium tumefaciens, Agrobacterium tumefaciens IAM13299, Azorhizobium caulinodans, Azorhizobium caulinodans ORS 571, Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA 110, Mesorhizobium huakuii, Mesorhizobium huakuii CCBAU2609, Mesorhizobium loti, Mesorhizobium loti NZP2037, Rhizobium etli, Rhizobium leguminosarum bv. viciae, Rhizobium leguminosarum bv. viciae MNF300, Rhizobium tropici, Sinorhizobium fredii, Sinorhizobium fredii USDA205, Sinorhizobium meliloti, Sinorhizobium meliloti Rm1021
Microbiology
150
399-406
2004
1
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2
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2
3
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44
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1
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10
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1917-1923
1961
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