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BRENDA support

Literature summary for 6.4.1.3 extracted from

  • Hofherr, S.; Senac, J.S.; Chen, C.Y.; Palmer, D.; Ng, P.; Barry, M.A.
    Short-term rescue of neonatal lethality in a mouse model of propionic acidemia by gene therapy (2009), Hum. Gene Ther., 20, 169-180.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine stringent model of propionyl CoA carboxylase subunit A deficiency, where homozygous knock-out mice are born, but die within 36 hours. Injection of vectors expressing propionyl CoA carboxylase subunit A significantly increases the lifespan for both unmodified and polyethylene glycol modified vectors, but the rescue is transient Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information stringent model of propionyl CoA carboxylase subunit A deficiency, where homozygous knock-out mice are born, but die within 36 hours. Injection of vectors expressing propionyl CoA carboxylase subunit A significantly increases the lifespan for both unmodified and polyethylene glycol modified vectors, but the rescue is transient Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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