BRENDA - Enzyme Database show
show all sequences of 6.4.1.3

Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula. Carboxylating enzyme in the 3-hydroxypropionate cycle for autotrophic carbon fixation

Hugler, M.; Krieger, R.S.; Jahn, M.; Fuchs, G.; Eur. J. Biochem. 270, 736-744 (2003)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli
Metallosphaera sedula
Inhibitors
Inhibitors
Commentary
Organism
Structure
ADP
weak inhibition
Metallosphaera sedula
CoA
activity on propanoyl-CoA is more strongly inhibited than activity of acetyl-CoA
Metallosphaera sedula
malonyl-CoA
activity on propanoyl-CoA is more strongly inhibited than activity of acetyl-CoA
Metallosphaera sedula
succinyl-CoA
activity on propanoyl-CoA is more strongly inhibited than activity of acetyl-CoA
Metallosphaera sedula
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.04
-
ATP
pH 7.5, 65°C
Metallosphaera sedula
0.06
-
acetyl-CoA
pH 7.5, 65°C
Metallosphaera sedula
0.07
-
propanoyl-CoA
pH 7.5, 65°C
Metallosphaera sedula
0.3
-
HCO3-
pH 7.5, 65°C
Metallosphaera sedula
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
10% of the activity with Mg2+
Metallosphaera sedula
Co2+
40% of the activity with Mg2+
Metallosphaera sedula
Mg2+
required for the formation of Mg-ATP complex, optimum concentration 5 mM at 5 mM ATP
Metallosphaera sedula
Mn2+
10% of the activity with Mg2+
Metallosphaera sedula
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
18600
-
alpha, beta, gamma, 4 * 57000 + 4 * 57000 + 4 * 18600, SDS-PAGE, biotin carboxylase (alpha subunit), carboxyl transferase (beta subunit) and biotin carrier protein (gamma subunit)
Metallosphaera sedula
57000
-
alpha, beta, gamma, 4 * 57000 + 4 * 57000 + 4 * 18600, SDS-PAGE, biotin carboxylase (alpha subunit), carboxyl transferase (beta subunit) and biotin carrier protein (gamma subunit)
Metallosphaera sedula
560000
-
gel filtration
Metallosphaera sedula
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + propanoyl-CoA + HCO3-
Chloroflexus aurantiacus
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
ADP + phosphate + (S)-methylmalonyl-CoA
-
Chloroflexus aurantiacus
?
ATP + propanoyl-CoA + HCO3-
Metallosphaera sedula
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
ADP + phosphate + (S)-methylmalonyl-CoA
-
Metallosphaera sedula
?
ATP + propanoyl-CoA + HCO3-
Sulfolobus metallicus
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
ADP + phosphate + (S)-methylmalonyl-CoA
-
Sulfolobus metallicus
?
ATP + propanoyl-CoA + HCO3-
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
ADP + phosphate + (S)-methylmalonyl-CoA
-
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
ATP + propanoyl-CoA + HCO3-
Chloroflexus aurantiacus OK-70-fl / DSM 636
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
ADP + phosphate + (S)-methylmalonyl-CoA
-
Chloroflexus aurantiacus OK-70-fl / DSM 636
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Chloroflexus aurantiacus
-
-
-
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
-
-
Metallosphaera sedula
-
-
-
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
-
-
Sulfolobus metallicus
-
DSM 6482
-
Purification (Commentary)
Commentary
Organism
-
Metallosphaera sedula
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.3
-
purified enzyme, pH 7.5, 65°C
Metallosphaera sedula
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + acetyl-CoA + HCO3-
EC 6.4.1.2 activity
651169
Chloroflexus aurantiacus
ADP + phosphate + malonyl-CoA
-
651169
Chloroflexus aurantiacus
?
ATP + acetyl-CoA + HCO3-
EC 6.4.1.2 activity
651169
Metallosphaera sedula
ADP + phosphate + malonyl-CoA
-
651169
Metallosphaera sedula
?
ATP + acetyl-CoA + HCO3-
EC 6.4.1.2 activity
651169
Sulfolobus metallicus
ADP + phosphate + malonyl-CoA
-
651169
Sulfolobus metallicus
?
ATP + acetyl-CoA + HCO3-
EC 6.4.1.2 activity
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
ADP + phosphate + malonyl-CoA
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
ATP + acetyl-CoA + HCO3-
EC 6.4.1.2 activity
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
ADP + phosphate + malonyl-CoA
-
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
?
ATP + propanoyl-CoA + HCO3-
-
651169
Chloroflexus aurantiacus
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Chloroflexus aurantiacus
?
ATP + propanoyl-CoA + HCO3-
-
651169
Metallosphaera sedula
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula
?
ATP + propanoyl-CoA + HCO3-
-
651169
Sulfolobus metallicus
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Sulfolobus metallicus
?
ATP + propanoyl-CoA + HCO3-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
651169
Chloroflexus aurantiacus
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Chloroflexus aurantiacus
?
ATP + propanoyl-CoA + HCO3-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
651169
Metallosphaera sedula
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula
?
ATP + propanoyl-CoA + HCO3-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
651169
Sulfolobus metallicus
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Sulfolobus metallicus
?
ATP + propanoyl-CoA + HCO3-
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
ATP + propanoyl-CoA + HCO3-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
ATP + propanoyl-CoA + HCO3-
-
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
?
ATP + propanoyl-CoA + HCO3-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
?
GTP + propanoyl-CoA + HCO3-
10% of the activity with ATP
651169
Metallosphaera sedula
GDP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula
?
GTP + propanoyl-CoA + HCO3-
10% of the activity with ATP
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
GDP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
UTP + propanoyl-CoA + HCO3-
40% of the activity with ATP
651169
Metallosphaera sedula
UDP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula
?
UTP + propanoyl-CoA + HCO3-
40% of the activity with ATP
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
UDP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
Subunits
Subunits
Commentary
Organism
dodecamer
alpha, beta, gamma, 4 * 57000 + 4 * 57000 + 4 * 18600, SDS-PAGE, biotin carboxylase (alpha subunit), carboxyl transferase (beta subunit) and biotin carrier protein (gamma subunit)
Metallosphaera sedula
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
75
-
-
Metallosphaera sedula
Temperature Range [°C]
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
40
85
-
Metallosphaera sedula
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
2
8
propanoyl-CoA
pH 7.5, 65°C
Metallosphaera sedula
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
-
Metallosphaera sedula
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6
8.5
-
Metallosphaera sedula
Cofactor
Cofactor
Commentary
Organism
Structure
biotin
bound to enzyme
Chloroflexus aurantiacus
biotin
bound to enzyme
Metallosphaera sedula
biotin
bound to enzyme
Sulfolobus metallicus
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli
Metallosphaera sedula
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
biotin
bound to enzyme
Chloroflexus aurantiacus
biotin
bound to enzyme
Metallosphaera sedula
biotin
bound to enzyme
Sulfolobus metallicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
ADP
weak inhibition
Metallosphaera sedula
CoA
activity on propanoyl-CoA is more strongly inhibited than activity of acetyl-CoA
Metallosphaera sedula
malonyl-CoA
activity on propanoyl-CoA is more strongly inhibited than activity of acetyl-CoA
Metallosphaera sedula
succinyl-CoA
activity on propanoyl-CoA is more strongly inhibited than activity of acetyl-CoA
Metallosphaera sedula
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.04
-
ATP
pH 7.5, 65°C
Metallosphaera sedula
0.06
-
acetyl-CoA
pH 7.5, 65°C
Metallosphaera sedula
0.07
-
propanoyl-CoA
pH 7.5, 65°C
Metallosphaera sedula
0.3
-
HCO3-
pH 7.5, 65°C
Metallosphaera sedula
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
10% of the activity with Mg2+
Metallosphaera sedula
Co2+
40% of the activity with Mg2+
Metallosphaera sedula
Mg2+
required for the formation of Mg-ATP complex, optimum concentration 5 mM at 5 mM ATP
Metallosphaera sedula
Mn2+
10% of the activity with Mg2+
Metallosphaera sedula
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
18600
-
alpha, beta, gamma, 4 * 57000 + 4 * 57000 + 4 * 18600, SDS-PAGE, biotin carboxylase (alpha subunit), carboxyl transferase (beta subunit) and biotin carrier protein (gamma subunit)
Metallosphaera sedula
57000
-
alpha, beta, gamma, 4 * 57000 + 4 * 57000 + 4 * 18600, SDS-PAGE, biotin carboxylase (alpha subunit), carboxyl transferase (beta subunit) and biotin carrier protein (gamma subunit)
Metallosphaera sedula
560000
-
gel filtration
Metallosphaera sedula
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + propanoyl-CoA + HCO3-
Chloroflexus aurantiacus
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
ADP + phosphate + (S)-methylmalonyl-CoA
-
Chloroflexus aurantiacus
?
ATP + propanoyl-CoA + HCO3-
Metallosphaera sedula
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
ADP + phosphate + (S)-methylmalonyl-CoA
-
Metallosphaera sedula
?
ATP + propanoyl-CoA + HCO3-
Sulfolobus metallicus
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
ADP + phosphate + (S)-methylmalonyl-CoA
-
Sulfolobus metallicus
?
ATP + propanoyl-CoA + HCO3-
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
ADP + phosphate + (S)-methylmalonyl-CoA
-
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
ATP + propanoyl-CoA + HCO3-
Chloroflexus aurantiacus OK-70-fl / DSM 636
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
ADP + phosphate + (S)-methylmalonyl-CoA
-
Chloroflexus aurantiacus OK-70-fl / DSM 636
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Metallosphaera sedula
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.3
-
purified enzyme, pH 7.5, 65°C
Metallosphaera sedula
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + acetyl-CoA + HCO3-
EC 6.4.1.2 activity
651169
Chloroflexus aurantiacus
ADP + phosphate + malonyl-CoA
-
651169
Chloroflexus aurantiacus
?
ATP + acetyl-CoA + HCO3-
EC 6.4.1.2 activity
651169
Metallosphaera sedula
ADP + phosphate + malonyl-CoA
-
651169
Metallosphaera sedula
?
ATP + acetyl-CoA + HCO3-
EC 6.4.1.2 activity
651169
Sulfolobus metallicus
ADP + phosphate + malonyl-CoA
-
651169
Sulfolobus metallicus
?
ATP + acetyl-CoA + HCO3-
EC 6.4.1.2 activity
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
ADP + phosphate + malonyl-CoA
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
ATP + acetyl-CoA + HCO3-
EC 6.4.1.2 activity
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
ADP + phosphate + malonyl-CoA
-
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
?
ATP + propanoyl-CoA + HCO3-
-
651169
Chloroflexus aurantiacus
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Chloroflexus aurantiacus
?
ATP + propanoyl-CoA + HCO3-
-
651169
Metallosphaera sedula
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula
?
ATP + propanoyl-CoA + HCO3-
-
651169
Sulfolobus metallicus
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Sulfolobus metallicus
?
ATP + propanoyl-CoA + HCO3-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
651169
Chloroflexus aurantiacus
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Chloroflexus aurantiacus
?
ATP + propanoyl-CoA + HCO3-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
651169
Metallosphaera sedula
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula
?
ATP + propanoyl-CoA + HCO3-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
651169
Sulfolobus metallicus
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Sulfolobus metallicus
?
ATP + propanoyl-CoA + HCO3-
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
ATP + propanoyl-CoA + HCO3-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
ATP + propanoyl-CoA + HCO3-
-
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
?
ATP + propanoyl-CoA + HCO3-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
ADP + phosphate + (S)-methylmalonyl-CoA
-
651169
Chloroflexus aurantiacus OK-70-fl / DSM 636
?
GTP + propanoyl-CoA + HCO3-
10% of the activity with ATP
651169
Metallosphaera sedula
GDP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula
?
GTP + propanoyl-CoA + HCO3-
10% of the activity with ATP
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
GDP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
UTP + propanoyl-CoA + HCO3-
40% of the activity with ATP
651169
Metallosphaera sedula
UDP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula
?
UTP + propanoyl-CoA + HCO3-
40% of the activity with ATP
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
UDP + phosphate + (S)-methylmalonyl-CoA
-
651169
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
?
Subunits (protein specific)
Subunits
Commentary
Organism
dodecamer
alpha, beta, gamma, 4 * 57000 + 4 * 57000 + 4 * 18600, SDS-PAGE, biotin carboxylase (alpha subunit), carboxyl transferase (beta subunit) and biotin carrier protein (gamma subunit)
Metallosphaera sedula
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
75
-
-
Metallosphaera sedula
Temperature Range [°C] (protein specific)
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
40
85
-
Metallosphaera sedula
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
2
8
propanoyl-CoA
pH 7.5, 65°C
Metallosphaera sedula
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
-
Metallosphaera sedula
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6
8.5
-
Metallosphaera sedula
Other publictions for EC 6.4.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745766
Collard
Import of TAT-conjugated prop ...
Homo sapiens
Mol. Cell. Biol.
38
e00491
2018
-
1
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745187
Vandova
Heterologous expression of di ...
Streptomyces coelicolor
J. Antibiot.
70
859-863
2017
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745501
Chapman
Propionyl-CoA carboxylase pcc ...
Caenorhabditis elegans
J. Inherit. Metab. Dis.
41
157-168
2017
-
-
-
-
-
-
-
-
2
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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Crystal structure of the alpha ...
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Enhanced FK506 production in S ...
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Unusual presentation of propio ...
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Evidence for catabolic pathway ...
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Liver transplantation in a pat ...
Homo sapiens
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Lymphocyte propionyl-CoA carbo ...
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Metabolic pathway engineering ...
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Rodriguez-Pombo
Towards a model to explain the ...
Homo sapiens
Biochim. Biophys. Acta
1740
489-498
2005
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662392
Jiang
Characterization of four varia ...
Homo sapiens
J. Biol. Chem.
280
27719-27727
2005
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661098
Diacovich
Crystal structure of the beta- ...
Streptomyces coelicolor
Biochemistry
43
14027-14036
2004
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662786
Dunn
Biochemical characterization o ...
Agrobacterium tumefaciens, Agrobacterium tumefaciens IAM13299, Azorhizobium caulinodans, Azorhizobium caulinodans ORS 571, Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA 110, Mesorhizobium huakuii, Mesorhizobium huakuii CCBAU2609, Mesorhizobium loti, Mesorhizobium loti NZP2037, Rhizobium etli, Rhizobium leguminosarum bv. viciae, Rhizobium leguminosarum bv. viciae MNF300, Rhizobium tropici, Sinorhizobium fredii, Sinorhizobium fredii USDA205, Sinorhizobium meliloti, Sinorhizobium meliloti Rm1021
Microbiology
150
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2004
1
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1
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651169
Hugler
Characterization of acetyl-CoA ...
Chloroflexus aurantiacus, Chloroflexus aurantiacus OK-70-fl / DSM 636, Metallosphaera sedula, Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348, Sulfolobus metallicus
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1
1
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3
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1
3
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3
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1
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19
1
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Chuakrut
Characterization of a bifuncti ...
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2003
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651459
Chloupkova
Propionic acidemia: analysis o ...
Homo sapiens
Hum. Mutat.
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2002
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651406
Schrick
cDNA cloning, mapping and expr ...
Homo sapiens, Mus musculus
Gene
264
147-152
2001
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2
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2
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653247
Muro
Effect of PCCB gene mutations ...
Homo sapiens
Mol. Genet. Metab.
74
476-483
2001
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12
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1
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1
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1
1
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12
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1
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2
1
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652691
Muro
Mutations affecting the beta-b ...
Homo sapiens
J. Inherit. Metab. Dis.
23
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2000
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1
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653246
Chloupkova
Changes in the carboxyl termin ...
Homo sapiens
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71
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2000
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651638
Menendez
Presence of acetyl coenzyme A ...
Acidianus infernus, Acidianus infernus So4a / DSM 3191, Chloroflexus aurantiacus, Chloroflexus aurantiacus OK-70-fl / DSM 636, Metallosphaera sedula, Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348, Sulfolobus metallicus, Sulfolobus metallicus Kra23 / DSM 6482
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16
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4
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