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Literature summary for 6.4.1.2 extracted from

  • Keil, S.; Mueller, M.; Zoller, G.; Haschke, G.; Schroeter, K.; Glien, M.; Ruf, S.; Focken, I.; Herling, A.W.; Schmoll, D.
    Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation (2010), J. Med. Chem., 53, 8679-8687.
    View publication on PubMed
Search for more literature for 6.4.1.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in baculovirus-infected High Five insect cells as N-terminal His-tagged fusion proteins Homo sapiens
expressed in baculovirus-infected High Five insect cells as N-terminal His-tagged fusion proteins Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
-
 Homo sapiens
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
 Homo sapiens
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
-
 Homo sapiens
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
 Homo sapiens
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
 Homo sapiens
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
 Homo sapiens
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
 Homo sapiens
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide moderate selective isoform ACC2 inhibitor Homo sapiens
N-(3-[cis-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
-
 Homo sapiens
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
-
 Homo sapiens
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
-
 Homo sapiens
N-[(2R)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
-
 Homo sapiens
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
-
 Homo sapiens
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
-
 Homo sapiens
N-[(R)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide submicromolar dualACC1/2 inhibitor Homo sapiens
N-[(R)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide submicromolar dualACC1/2 inhibitor Rattus norvegicus
N-[(S)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide submicromolar dualACC1/2 inhibitor Homo sapiens
N-[(S)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide submicromolar dualACC1/2 inhibitor Rattus norvegicus
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
-
 Homo sapiens
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
-
 Homo sapiens
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
 Homo sapiens
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
-
 Homo sapiens
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-affinity column chromatography and gel filtration Homo sapiens
Ni-affinity column chromatography and gel filtration Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Homo sapiens ADP + malonyl-CoA + phosphate
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + malonyl-CoA + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ACC1 isoform Homo sapiens
ACC1 isoform Rattus norvegicus
ACC2 isoform Homo sapiens
ACC2 isoform Rattus norvegicus
Acetyl CoA carboxylase
-
 Homo sapiens
Acetyl CoA carboxylase
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000015
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00003
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00006
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
0.00006
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
0.00007
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
0.00007
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
0.00008
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00008
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.0001
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.00014
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00014
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.00015
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens 1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
0.00017
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00019
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00019
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.00019
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.0002
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.0002
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0002
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.00021
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.00025
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
0.00027
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.00028
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
0.00036
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.00038
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
0.0004
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.0004
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.00059
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
0.0006
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
0.00062
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.00063
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
0.00067
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
0.0007
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.0007
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
0.0007
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.0007
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.00075
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0008
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.00091
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
0.00092
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0011
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0011
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00114
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.0012
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0012
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
0.0012
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens 1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
0.0012
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.00128
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
0.00178
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0018
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0019
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.0021
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0021
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.0023
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
0.0026
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0026
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.00265
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.0027
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.0029
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0029
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
0.0029
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens 1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
0.003
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
0.003
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens 1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
0.0032
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.0039
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
0.00452
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0057
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
0.0067
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00675
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0074
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
0.0078
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.0079
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0079
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.0099
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.01
-
 IC50 above 0.01 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
0.0105
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
0.011
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
0.012
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.012
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.0127
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.013
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.014
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
0.017
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.017
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
0.02
-
 isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
0.025
-
 isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-(3-[cis-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.03
-
 IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication Homo sapiens N-[(2R)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide