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Literature summary for 6.4.1.2 extracted from

  • Haque, T.S.; Liang, N.; Golla, R.; Seethala, R.; Ma, Z.; Ewing, W.R.; Cooper, C.B.; Pelleymounter, M.A.; Poss, M.A.; Cheng, D.
    Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase (2009), Bioorg. Med. Chem. Lett., 19, 5872-5876.
    View publication on PubMed
Search for more literature for 6.4.1.2

Application

Application Comment Organism
drug development the enzyme is a target for drug development in treatment of obesity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
 Homo sapiens
2-methoxy-N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
 Homo sapiens
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
 Homo sapiens
2-methyl-N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)propanamide
-
 Homo sapiens
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
 Homo sapiens
ethyl (1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)carbamate
-
 Homo sapiens
ethyl (1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)carbamate
-
 Homo sapiens
ethyl(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)carbamate
-
 Homo sapiens
additional information synthesis and enzymatic evaluation of potent inhibitors of acetyl-CoA carboxylases containing biphenyl or 3-phenyl pyridine cores Homo sapiens
N-(1-(2'-methyl-4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
 Homo sapiens
N-(1-(2,2'-dimethyl-4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
 Homo sapiens
N-(1-(2-methyl-4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
 Homo sapiens
N-(1-(4'-[4-(2-methoxyethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
 Homo sapiens
N-(1-(4'-[4-(benzyloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
 Homo sapiens
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
 Homo sapiens
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
 Homo sapiens
N-(1-(4-[6-(3-phenoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
 Homo sapiens
N-(1-(4-[6-(4-ethoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
 Homo sapiens
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)-1H-pyrazole-4-carboxamide
-
 Homo sapiens
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
 Homo sapiens
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)butanamide
-
 Homo sapiens
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)cyclopropanecarboxamide
-
 Homo sapiens
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)pentanamide
-
 Homo sapiens
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)propanamide
-
 Homo sapiens
N-(1-[4'-(3-butoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
 Homo sapiens
N-(1-[4'-(3-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
 Homo sapiens
N-(1-[4'-(3-methoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
 Homo sapiens
N-(1-[4'-(3-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
 Homo sapiens
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
-
 Homo sapiens
N-(1-[4'-(4-benzylphenoxy)biphenyl-4-yl]ethyl)acetamide
-
 Homo sapiens
N-(1-[4'-(4-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
 Homo sapiens
N-(1-[4'-(4-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
 Homo sapiens
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
 Homo sapiens
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)butanamide
-
 Homo sapiens
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
-
 Homo sapiens
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)pentanamide
-
 Homo sapiens
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
 Homo sapiens
N-(1-[4'-(4-propylphenoxy)biphenyl-4-yl]ethyl)acetamide
-
 Homo sapiens
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
-
 Homo sapiens
N-[1-(4-(6-[4-(benzyloxy)phenoxy]pyridin-3-yl)phenyl)ethyl]acetamide
-
 Homo sapiens
N-[1-(4-(6-[4-(propan-2-yloxy)phenoxy]pyridin-3-yl)phenyl)ethyl]acetamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
ACC1
-
 Homo sapiens
ACC2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000007
-
 ACC2 Homo sapiens N-(1-[4'-(4-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000012
-
 ACC2 Homo sapiens N-(1-[4'-(3-butoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000013
-
 ACC1 Homo sapiens N-(1-[4'-(3-butoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000014
-
 ACC1 Homo sapiens N-(1-[4'-(4-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000014
-
 ACC2 Homo sapiens N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000016
-
 ACC2 Homo sapiens N-(1-[4'-(3-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000017
-
 ACC1 Homo sapiens N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000017
-
 ACC1 Homo sapiens N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.000033
-
 ACC2 Homo sapiens N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.000035
-
 ACC1 Homo sapiens N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.000036
-
 ACC1 Homo sapiens N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
0.000039
-
 ACC1 Homo sapiens N-(1-[4'-(4-benzylphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000041
-
 ACC1 Homo sapiens N-(1-[4'-(3-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000047
-
 ACC1 Homo sapiens N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
0.000081
-
 ACC1 Homo sapiens N-(1-[4'-(4-propylphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000089
-
 ACC1 Homo sapiens N-(1-(4'-[4-(2-methoxyethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.000113
-
 ACC2 Homo sapiens N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.000114
-
 ACC2 Homo sapiens N-(1-[4'-(4-propylphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000119
-
 ACC2 Homo sapiens N-(1-[4'-(4-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.00014
-
 ACC1 Homo sapiens N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
0.000188
-
 ACC1 Homo sapiens 2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
0.000202
-
 ACC2 Homo sapiens N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
0.000214
-
 ACC2 Homo sapiens 2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
0.000268
-
 ACC2 Homo sapiens N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
0.000296
-
 ACC1 Homo sapiens N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
0.000373
-
 ACC2 Homo sapiens N-(1-[4'-(3-methoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.00055
-
 ACC2 Homo sapiens N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
0.000609
-
 ACC2 Homo sapiens N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
0.000718
-
 ACC2 Homo sapiens 2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000753
-
 ACC1 Homo sapiens 2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000945
-
 ACC2 Homo sapiens N-(1-[4'-(4-benzylphenoxy)biphenyl-4-yl]ethyl)acetamide
0.00102
-
 ACC2 Homo sapiens N-(1-[4'-(3-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.00163
-
 ACC1 Homo sapiens N-(1-[4'-(4-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.00184
-
 ACC2 Homo sapiens 2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
0.00206
-
 ACC1 Homo sapiens 2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
0.00277
-
 ACC1 Homo sapiens N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)butanamide
0.00858
-
 ACC1 Homo sapiens N-(1-[4'-(3-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.03
-
 above, ACC1 Homo sapiens N-(1-(4'-[4-(benzyloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.03
-
 above, ACC2 Homo sapiens N-(1-(4'-[4-(benzyloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.03
-
 ACC1 Homo sapiens N-(1-[4'-(3-methoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.03
-
 ACC1 Homo sapiens N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)pentanamide
0.03
-
 ACC1 Homo sapiens ethyl(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)carbamate
0.03
-
 ACC2 Homo sapiens N-(1-(4'-[4-(2-methoxyethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.03
-
 ACC2 Homo sapiens N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)butanamide
0.03
-
 ACC2 Homo sapiens N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)pentanamide
0.031
-
 ACC2 Homo sapiens ethyl(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)carbamate