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Literature summary for 6.4.1.2 extracted from
- Regulation of acetyl-CoA carboxylase (2006), Biochem. Soc. Trans., 34, 223-227.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| biotin | dependent | Rattus norvegicus |  |
| biotin | dependent | Homo sapiens | |
| citrate | - |
Rattus norvegicus | |
| citrate | - |
Homo sapiens | |
| glutamate | - |
Rattus norvegicus | |
| Insulin | ACC specific activity is increased in response to insulin | Rattus norvegicus | |
| Insulin | ACC specific activity is increased in response to insulin | Homo sapiens | |
| L-glutamate | - |
Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CoA | - |
Homo sapiens | |
| CoA | - |
Rattus norvegicus | |
| fatty acyl-CoA ester | - |
Homo sapiens | |
| fatty acyl-CoA ester | - |
Rattus norvegicus | |
| leptin | - |
Rattus norvegicus | |
| malonyl-CoA | - |
Homo sapiens | |
| malonyl-CoA | - |
Rattus norvegicus | |
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
| pyridoxal phosphate | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 265000 | - |
predicted mass | Homo sapiens |
| 280000 | - |
predicted mass | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13085 | - |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Homo sapiens | - |
| heart | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| mammary gland | - |
Homo sapiens | - |
| skeletal muscle | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
ir | |
| ATP + acetyl-CoA + HCO3- | - |
Homo sapiens | ADP + phosphate + malonyl-CoA | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACC-1 | - |
Homo sapiens |
| ACC-2 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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