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Literature summary for 6.4.1.2 extracted from

  • Boone, A.N.; Chan, A.; Kulpa, J.E.; Brownsey, R.W.
    Bimodal activation of acetyl-CoA carboxylase by glutamate (2000), J. Biol. Chem., 275, 10819-10825.
    View publication on PubMed
Search for more literature for 6.4.1.2

Activating Compound

Activating Compound Comment Organism Structure
citrate
-
 Rattus norvegicus
glutamate role as physiological activator postulated, 4fold activation in absence of citrate, affects phosphorylation of enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
NaCl 30% inhibition at 100 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetyl-CoA + HCO3- Rattus norvegicus key enzyme of fatty acid biosynthesis ADP + phosphate + malonyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein down-regulates enzyme activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?

Cofactor

Cofactor Comment Organism Structure
biotin enzyme-bound Rattus norvegicus