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Literature summary for 6.4.1.2 extracted from

  • Brownsey, R.W.; Zhande, R.; Boone, A.N.
    Isoforms of acetyl-CoA carboxylase: structures, regulatory properties and metabolic functions (1997), Biochem. Soc. Trans., 25, 1232-1238.
    View publication on PubMed
Search for more literature for 6.4.1.2

Organism

Organism UniProt Comment Textmining
Anabaena sp.
-
-
-
Cyclotella cryptica
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Mammalia
-
-
-
Metazoa
-
-
-
Pseudomonas sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue white and brown Mammalia
-
mammary gland lactating Mammalia
-
additional information differential distribution of acetyl-CoA carboxylase isoforms in mammalian tissues Mammalia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Mammalia ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Escherichia coli ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Homo sapiens ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Pseudomonas sp. ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Metazoa ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Anabaena sp. ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Cyclotella cryptica ADP + phosphate + malonyl-CoA
-
 ?

Subunits

Subunits Comment Organism
?
-
 Homo sapiens
? x * 265000-280000, exist minimally as dimers under non-denaturing conditions. When activated by dicarboxylic acids and tricarboxylic acids, which induce aggregation into elongated polymers it consists of 5-20 dimers. Two major form of animal acety-CoA carboxylase: ACC1 is the 265000 MW ACC-alpha-isoform, ACC-2 is the 275000-280000 MW ACC-beta-isoform Metazoa
? 4 component polypeptides: 1. Biotin carrier protein, MW 170000, 2. biotin carboxylase, which assembles as a dimer of two 49000 MW subunits, 3. and 4. the alpha-subunit and beta-subunit of carboxyl transferase, which assemble as a 130000 MW alpha2beta2 tetramer Escherichia coli