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Literature summary for 6.4.1.2 extracted from
- Acetyl-CoA carboxylase from rat mammary gland (1975), Methods Enzymol., 35B, 11-17.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bovine serum albumin | - |
Rattus norvegicus | |
| citrate | completely inactive in absence of the allosteric activator citrate | Rattus norvegicus |  |
| citrate | 6fold stimulation by 0.03 M citrate | Rattus norvegicus | |
| Phospholipids | stimulate | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Avidin | biotin prevents inhibition | Rattus norvegicus | |
| laurate | - |
Rattus norvegicus | |
| malonyl-CoA | - |
Rattus norvegicus | |
| Mg2+ | at high concentrations | Rattus norvegicus | |
| myristate | - |
Rattus norvegicus | |
| palmitoyl-CoA | - |
Rattus norvegicus | |
| Rat milk | - |
Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.045 | - |
propionyl-CoA | - |
Rattus norvegicus | |
| 0.05 | - |
acetyl-CoA | - |
Rattus norvegicus | |
| 0.0588 | - |
ATP | second value 0.227 mM | Rattus norvegicus | |
| 0.227 | - |
ATP | second value 0.0588 mM | Rattus norvegicus | |
| 10 | - |
HCO3- | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | activates | Rattus norvegicus | |
| Mn2+ | activates | Rattus norvegicus | |
| Mn2+ | maximal activity at 8 mM | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mammary gland | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? | |
| ATP + propionyl-CoA + HCO3- | maximal rate is 20% of that for acetyl-CoA | Rattus norvegicus | ADP + phosphate + methylmalonyl-CoA | - |
? | |
| dATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | dADP + phosphate + malonyl-CoA | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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