Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.4.1.2 extracted from

  • Tanabe, T.; Nakanishi, S.; Hashimoto, T.; Ogiwara, H.; Nikawa, J.I.; Numa, S.
    Acetyl-CoA carboxylase from rat liver. EC 6.4.1.2 Acetyl-CoA:carbon-dioxide ligase (ADP-forming) (1981), Methods Enzymol., 71, 5-16.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
citrate nearly absolute requirement for tricarboxylate activators such as citrate or isocitrate Rattus norvegicus
isocitrate nearly absolute requirement for tricarboxylate activators such as citrate or isocitrate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-(4-Chlorophenoxy)-2-methylpropionate
-
Rattus norvegicus
2-Methyl-2-[p-(1,2,3,4-tetrahydro-1-naphthyl)-phenoxy]propionic acid
-
Rattus norvegicus
Arachidonoyl-CoA
-
Rattus norvegicus
arachidoyl-CoA
-
Rattus norvegicus
docosanoyl-CoA
-
Rattus norvegicus
Kynurenate
-
Rattus norvegicus
lignoceroyl-CoA
-
Rattus norvegicus
linolenoyl-CoA
-
Rattus norvegicus
linoleoyl-CoA
-
Rattus norvegicus
long-chain acyl-CoA thioesters
-
Rattus norvegicus
myristoyl-CoA
-
Rattus norvegicus
oleoyl-CoA
-
Rattus norvegicus
palmitoleoyl-CoA
-
Rattus norvegicus
palmitoyl-1,N6-etheno-CoA
-
Rattus norvegicus
Palmitoyl-4'-phosphopantetheine
-
Rattus norvegicus
palmitoyl-CoA
-
Rattus norvegicus
palmitoyl-dephospho-CoA
-
Rattus norvegicus
Palmitoyl-inosino-CoA
-
Rattus norvegicus
Palmitoyl-keto-CoA
-
Rattus norvegicus
S-cetyl-CoA
-
Rattus norvegicus
stearoyl-CoA
-
Rattus norvegicus
xanthurenate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015
-
ATP
-
Rattus norvegicus
0.016
-
malonyl-CoA
-
Rattus norvegicus
0.025
-
acetyl-CoA
-
Rattus norvegicus
1.25
-
acetodethio-CoA
-
Rattus norvegicus
2.5
-
HCO3- hindlimb muscle Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
phosphate contains 2.1 mol phosphate per 215000 g of protein Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
230000
-
x * 230000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA ordered bi bi uni uni ping-pong mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.05
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetodethio-CoA + HCO3-
-
Rattus norvegicus ?
-
?
ATP + acetyl-CoA + HCO3-
-
Rattus norvegicus ADP + phosphate + malonyl-CoA
-
?

Subunits

Subunits Comment Organism
? x * 230000, SDS-PAGE Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
biotin contains 1 mol of biotin per 237000 g of enzyme Rattus norvegicus