Activating Compound | Comment | Organism | Structure |
---|---|---|---|
citrate | nearly absolute requirement for tricarboxylate activators such as citrate or isocitrate | Rattus norvegicus | |
isocitrate | nearly absolute requirement for tricarboxylate activators such as citrate or isocitrate | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(4-Chlorophenoxy)-2-methylpropionate | - |
Rattus norvegicus | |
2-Methyl-2-[p-(1,2,3,4-tetrahydro-1-naphthyl)-phenoxy]propionic acid | - |
Rattus norvegicus | |
Arachidonoyl-CoA | - |
Rattus norvegicus | |
arachidoyl-CoA | - |
Rattus norvegicus | |
docosanoyl-CoA | - |
Rattus norvegicus | |
Kynurenate | - |
Rattus norvegicus | |
lignoceroyl-CoA | - |
Rattus norvegicus | |
linolenoyl-CoA | - |
Rattus norvegicus | |
linoleoyl-CoA | - |
Rattus norvegicus | |
long-chain acyl-CoA thioesters | - |
Rattus norvegicus | |
myristoyl-CoA | - |
Rattus norvegicus | |
oleoyl-CoA | - |
Rattus norvegicus | |
palmitoleoyl-CoA | - |
Rattus norvegicus | |
palmitoyl-1,N6-etheno-CoA | - |
Rattus norvegicus | |
Palmitoyl-4'-phosphopantetheine | - |
Rattus norvegicus | |
palmitoyl-CoA | - |
Rattus norvegicus | |
palmitoyl-dephospho-CoA | - |
Rattus norvegicus | |
Palmitoyl-inosino-CoA | - |
Rattus norvegicus | |
Palmitoyl-keto-CoA | - |
Rattus norvegicus | |
S-cetyl-CoA | - |
Rattus norvegicus | |
stearoyl-CoA | - |
Rattus norvegicus | |
xanthurenate | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
ATP | - |
Rattus norvegicus | |
0.016 | - |
malonyl-CoA | - |
Rattus norvegicus | |
0.025 | - |
acetyl-CoA | - |
Rattus norvegicus | |
1.25 | - |
acetodethio-CoA | - |
Rattus norvegicus | |
2.5 | - |
HCO3- | hindlimb muscle | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
phosphate | contains 2.1 mol phosphate per 215000 g of protein | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
230000 | - |
x * 230000, SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA | ordered bi bi uni uni ping-pong mechanism | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
6.05 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetodethio-CoA + HCO3- | - |
Rattus norvegicus | ? | - |
? | |
ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 230000, SDS-PAGE | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
biotin | contains 1 mol of biotin per 237000 g of enzyme | Rattus norvegicus |