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Literature summary for 6.4.1.1 extracted from

  • Libor, S.M.; Sundaram, T.K.; Scrutton, M.C.
    Pyruvate carboxylase from a thermophilic Bacillus (1978), Biochem. J., 169, 543-558.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
acetyl-CoA
-
Gallus gallus
acetyl-CoA activates Rattus norvegicus
acetyl-CoA activates Bacillus sp. (in: Bacteria)
acetyl-CoA best activator Bacillus sp. (in: Bacteria)
acetyl-CoA in absence of acetyl-CoA the maximal rate of oxaloacetate synthesis is 20% of that obtained in presence of saturating concentrations of acetyl-CoA Bacillus sp. (in: Bacteria)
acyl-CoA derivatives activate Bacillus sp. (in: Bacteria)
methanesulfonyl-CoA activates Saccharomyces cerevisiae
methanesulfonyl-CoA activates Bacillus sp. (in: Bacteria)
methanesulfonyl-CoA inhibition Gallus gallus
methanesulfonyl-CoA inhibition Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate
-
Gallus gallus
2-oxoglutarate
-
Rattus norvegicus
methanesulfonyl-CoA activation Bacillus sp. (in: Bacteria)
methanesulfonyl-CoA
-
Gallus gallus
methanesulfonyl-CoA
-
Rattus norvegicus
methanesulfonyl-CoA activation Saccharomyces cerevisiae
Trinitrobenzenesulfonate inactivation of acetyl-CoA dependent activity, no effect on activator-independent activity Bacillus sp. (in: Bacteria)
Trinitrobenzenesulfonate
-
Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
16
-
HCO3- with saturating concentrations of the activator acetyl-CoA Bacillus sp. (in: Bacteria)
400
-
HCO3- without acetyl-CoA Bacillus sp. (in: Bacteria)

Organism

Organism UniProt Comment Textmining
Bacillus sp. (in: Bacteria)
-
thermophilic
-
Gallus gallus
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate + HCO3-
-
Gallus gallus ADP + phosphate + oxaloacetate
-
?
ATP + pyruvate + HCO3-
-
Rattus norvegicus ADP + phosphate + oxaloacetate
-
?
ATP + pyruvate + HCO3-
-
Saccharomyces cerevisiae ADP + phosphate + oxaloacetate
-
?
ATP + pyruvate + HCO3-
-
Bacillus sp. (in: Bacteria) ADP + phosphate + oxaloacetate
-
?