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Literature summary for 6.3.5.4 extracted from

  • Richards, N.G.; Kilberg, M.S.
    Asparagine synthetase chemotherapy (2006), Annu. Rev. Biochem., 75, 629-654.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.5.4

Activating Compound

Activating Compound Comment Organism Structure
Phytohemagglutinin
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
E348D mutant forms two molecules of diphosphate per asparagine Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
beta-asparaginyladenylate
-
 Homo sapiens
mupirocin
-
 Homo sapiens
phosmidosine
-
 Homo sapiens
sulfoximine adenylate most potent inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukemia cell
-
 Homo sapiens
-
MOLT-4 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-Asp + L-Gln
-
 Escherichia coli AMP + diphosphate + L-Asn + L-Glu
-
 ?
ATP + L-aspartate + L-glutamine + H2O
-
 Homo sapiens AMP + diphosphate + L-asparagine + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
AS-B
-
 Escherichia coli
ASNS
-
 Homo sapiens
Asparagine synthetase
-
 Escherichia coli
asparagine synthetase, glutamine-dependent
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000285
-
 sulfoximine adenylate
-
 Homo sapiens