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Literature summary for 6.3.5.3 extracted from

  • Ambing, E.; Canaves, J.M.; Chiu, H.; Deacon, A.M.; DiDonato, M.; Elsliger, M.; Godzik, A.; Grittini, C.; Grzechnik, S.K.; Hale, J.; Hampton, E.; Han, G.W.; Haugen, J.; Jaroszewski, L.; Klock, H.E.; Koesema, E.; Kreusch, A.; Kuhn, P.; Lesley, S.A.; Levin, I.; Miller, M.D.; Moy, K.; Nigoghossian, E.; Paulsen, J.; Quijano, K.; Reyes, R.; Spraggon, G.; Stevens, R.C.; van den Bedem, H.; Velasquez, J.; White, A.; Wolf, G.; Xu, Q.; Hodgson, K.O.; Wooley, J.; Wilson, I. A.
    Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution (2006), Proteins Struct. Funct. Bioinform., 63, 1106-1111.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
nanodroplet vapor diffusion method, crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution Thermotoga maritima

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O Thermotoga maritima fourth step of the purine biosynthetic pathway ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate
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Organism

Organism UniProt Comment Textmining
Thermotoga maritima Q9X0X3
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O fourth step of the purine biosynthetic pathway Thermotoga maritima ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate
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Synonyms

Synonyms Comment Organism
FGAM FGAM is part of the de novo purine biosynthesis subsystem, where it forms a complex with purS (TM1244) and purQ (TM1245) to form formylglycinamide ribonucleotide amidotransferase (FGAR-AT) Thermotoga maritima
phosphoribosylformylglycinamidine synthase II phosphoribosylformylglycinamidine synthase II is part of the de novo purine biosynthesis subsystem, where it forms a complex with purS (TM1244) and purQ (TM1245) to form formylglycinamide ribonucleotide amidotransferase (FGAR-AT) Thermotoga maritima
smPurL
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Thermotoga maritima