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Literature summary for 6.3.5.10 extracted from

  • Warren, M.J.; Raux, E.; Schubert, H.L.; Escalante-Semerena, J.C.
    The biosynthesis of adenosylcobalamin (vitamin B12) (2002), Nat. Prod. Rep., 19, 390-412.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57000
-
2 * 57000 Pseudomonas denitrificans (nom. rej.)

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O Salmonella enterica CbiP is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, anaerobic pathway ADP + phosphate + adenosylcobyric acid + L-glutamate
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O Pseudomonas denitrificans (nom. rej.) CobQ is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, aerobic pathway ADP + phosphate + adenosylcobyric acid + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas denitrificans (nom. rej.)
-
-
-
Salmonella enterica
-
serovar typhimurium
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O CbiP is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, anaerobic pathway Salmonella enterica ADP + phosphate + adenosylcobyric acid + L-glutamate
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O CobQ is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, aerobic pathway Pseudomonas denitrificans (nom. rej.) ADP + phosphate + adenosylcobyric acid + L-glutamate
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O CbiP catalyzes b, d, e, and g amidation Salmonella enterica ADP + phosphate + adenosylcobyric acid + L-glutamate
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O CobQ amidates the side chains b, d, e, and g generating adenosylcobyric acid, requires glutamine as the amide donor Pseudomonas denitrificans (nom. rej.) ADP + phosphate + adenosylcobyric acid + L-glutamate
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 57000 Pseudomonas denitrificans (nom. rej.)

Synonyms

Synonyms Comment Organism
CbiP
-
Salmonella enterica
CobQ
-
Pseudomonas denitrificans (nom. rej.)

Cofactor

Cofactor Comment Organism Structure
ATP requirement Pseudomonas denitrificans (nom. rej.)