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Literature summary for 6.3.4.8 extracted from
- The enzymatic synthesis of 5'-phosphoribosylimidazoleacetic acid (1964), J. Biol. Chem., 239, 2593-2601.
General Stability
| General Stability | Organism |
|---|---|
| phosphate stabilizes | Oryctolagus cuniculus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0034 | - |
5-phosphoribosyl diphosphate | - |
Oryctolagus cuniculus |  |
| 0.218 | - |
ATP | - |
Oryctolagus cuniculus | |
| 0.372 | - |
imidazoleacetate | - |
Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate | Oryctolagus cuniculus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Oryctolagus cuniculus | - |
| liver | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00706 | - |
- |
Oryctolagus cuniculus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 0.001 M mercaptoethanol, 50% loss of activity after 1 week | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate | - |
Oryctolagus cuniculus | ? | - |
? | |
| ATP + imidazoleacetic acid + 5-phosphoribosyl diphosphate | - |
Oryctolagus cuniculus | ADP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate | - |
? | |
| CTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate | - |
Oryctolagus cuniculus | CDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate | - |
? | |
| GTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate | - |
Oryctolagus cuniculus | GDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
labile at | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 8.2 | - |
Oryctolagus cuniculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 9 | pH 7.2: about 50% of maximal activity, pH 9.0: about 25% of maximal activity | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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