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Literature summary for 6.3.4.5 extracted from

  • Sardar, A.; Jardim, A.; Ghosh, A.; Mandal, A.; Das, S.; Saini, S.; Abhishek, K.; Singh, R.; Verma, S.; Kumar, A.; Das, P.
    Genetic manipulation of Leishmania donovani to explore the involvement of argininosuccinate synthase in oxidative stress management (2016), PLoS Negl. Trop. Dis., 10, e0004308 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-citrulline + L-aspartate Leishmania donovani the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine AMP + diphosphate + 2-(Nomega-L-arginino)succinate
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?
ATP + L-citrulline + L-aspartate Leishmania donovani AG83 the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine AMP + diphosphate + 2-(Nomega-L-arginino)succinate
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?

Organism

Organism UniProt Comment Textmining
Leishmania donovani H9BG20
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-
Leishmania donovani AG83 H9BG20
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-

Source Tissue

Source Tissue Comment Organism Textmining
promastigote
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Leishmania donovani
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-citrulline + L-aspartate
-
Leishmania donovani AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
?
ATP + L-citrulline + L-aspartate the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine Leishmania donovani AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
?
ATP + L-citrulline + L-aspartate
-
Leishmania donovani AG83 AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
?
ATP + L-citrulline + L-aspartate the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine Leishmania donovani AG83 AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
?

General Information

General Information Comment Organism
malfunction a cell line lacking two of three LdASS-/-/+ alleles, with greatly reduced argininosuccinate synthase activity, is generated by a double-targeted gene replacement strategy in Leishmania donovani promastigote Leishmania donovani
metabolism the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine Leishmania donovani
physiological function argininosuccinate synthase is important for Leishmania donovani to survive in stressed environments and can be exploited as anti-leishmanial drug target Leishmania donovani