Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-citrulline + L-aspartate | Leishmania donovani | the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? | |
ATP + L-citrulline + L-aspartate | Leishmania donovani AG83 | the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | H9BG20 | - |
- |
Leishmania donovani AG83 | H9BG20 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
promastigote | - |
Leishmania donovani | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-citrulline + L-aspartate | - |
Leishmania donovani | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? | |
ATP + L-citrulline + L-aspartate | the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine | Leishmania donovani | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? | |
ATP + L-citrulline + L-aspartate | - |
Leishmania donovani AG83 | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? | |
ATP + L-citrulline + L-aspartate | the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine | Leishmania donovani AG83 | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | a cell line lacking two of three LdASS-/-/+ alleles, with greatly reduced argininosuccinate synthase activity, is generated by a double-targeted gene replacement strategy in Leishmania donovani promastigote | Leishmania donovani |
metabolism | the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine | Leishmania donovani |
physiological function | argininosuccinate synthase is important for Leishmania donovani to survive in stressed environments and can be exploited as anti-leishmanial drug target | Leishmania donovani |