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Literature summary for 6.3.4.5 extracted from

  • Miyamoto, T.; Lo, P.H.Y.; Saichi, N.; Ueda, K.; Hirata, M.; Tanikawa, C.; Matsuda, K.
    Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53 (2017), Sci. Adv., 3, e1603204 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus P16460
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-

Synonyms

Synonyms Comment Organism
argininosuccinate synthase 1
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Mus musculus
ASS1
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Mus musculus

Expression

Organism Comment Expression
Mus musculus argininosuccinate synthase 1 (ASS1), is directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism. x-Ray irradiation promotes the systemic induction of Ass1 up

General Information

General Information Comment Organism
physiological function argininosuccinate synthase 1 (ASS1), is directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism. x-Ray irradiation promotes the systemic induction of Ass1 and concomitantly increases plasma arginine levels in p53+/+ mice but not in p53-/- mice. Ass1+/- mice exhibit hypersensitivity to whole-body irradiation owing to increased apoptosis in the small intestinal crypts. ASS1 plays a pivotal role in limiting Akt phosphorylation. Aberrant activation of Akt resulting from ASS1 loss disrupts Akt-mediated cell survival signaling activity under genotoxic stress Mus musculus