Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P16460 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
argininosuccinate synthase 1 | - |
Mus musculus |
ASS1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | argininosuccinate synthase 1 (ASS1), is directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism. x-Ray irradiation promotes the systemic induction of Ass1 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | argininosuccinate synthase 1 (ASS1), is directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism. x-Ray irradiation promotes the systemic induction of Ass1 and concomitantly increases plasma arginine levels in p53+/+ mice but not in p53-/- mice. Ass1+/- mice exhibit hypersensitivity to whole-body irradiation owing to increased apoptosis in the small intestinal crypts. ASS1 plays a pivotal role in limiting Akt phosphorylation. Aberrant activation of Akt resulting from ASS1 loss disrupts Akt-mediated cell survival signaling activity under genotoxic stress | Mus musculus |