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Literature summary for 6.3.4.5 extracted from

  • Henriet, E.; Abou Hammoud, A.; Dupuy, J.W.; Dartigues, B.; Ezzoukry, Z.; Dugot-Senant, N.; Leste-Lasserre, T.; Pallares-Lupon, N.; Nikolski, M.; Le Bail, B.; Blanc, J.F.; Balabaud, C.; Bioulac-Sage, P.; Raymond, A.A.; Saltel, F.
    Argininosuccinate synthase 1 (ASS1) A marker of unclassified hepatocellular adenoma and high bleeding risk (2017), Hepatology, 66, 2016-2028 .
    View publication on PubMed
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Application

Application Comment Organism
medicine unclassified hepatocellular carcinomas display specific up-regulation of the arginine synthesis pathway associated with overexpression of argininosuccinate synthase (ASS1) and arginosuccinate lyase. All the unclassified hepatocellular carcinomas tested could be identified by ASS1 immunohistochemistry, and 64.7% of these carcinomas presented clinical bleeding manifestations. The significance of ASS1 also encompasses certain hemorrhagic cases, particularly inflammatory hepatocellular carcinomas Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00966
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Synonyms

Synonyms Comment Organism
ASS1
-
 Homo sapiens