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Literature summary for 6.3.4.5 extracted from

  • Delage, B.; Fennell, D.A.; Nicholson, L.; McNeish, I.; Lemoine, N.R.; Crook, T.; Szlosarek, P.W.
    Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer (2010), Int. J. Cancer, 126, 2762-2772.
    View publication on PubMed
Search for more literature for 6.3.4.5

Application

Application Comment Organism
medicine potential target in platinum sensitive tumours Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
caveola
-
 Homo sapiens 5901
-
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell line
-
 Homo sapiens
-
endothelial cell
-
 Homo sapiens
-
inflammatory cell
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Argininosuccinate synthetase
-
 Homo sapiens
ASS1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens tumoural enzyme downregulation by hepatocellular carcinoma, malignant melanoma, malignant pleural mesothelioma, prostate and renal cancer down
Homo sapiens hepatic argininosuccinate synthase expression is hormonally regulated, expression of endothelial and inflammatory cell argininosuccinate synthase is under control of cytokines additional information
Homo sapiens overexpression of argininosuccinate synthase in primary ovarian, stomach and colorectal cancer cells results in platinum sensitive tumours up

General Information

General Information Comment Organism
malfunction epigenetic silencing triggers apoptosis in arginine auxotroph tumours Homo sapiens
physiological function rate-limiting enzyme in urea and arginine(NO)-citrulline cycles Homo sapiens