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Literature summary for 6.3.4.5 extracted from
- Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells (2007), Am. J. Physiol. Heart Circ. Physiol., 293, H1115-H1121.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the downregulation of tumor necrosis factor-alpha is an added insult to endothelial function because of its important role in NO production and in endothelial viability | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell line | expression analysis is performed in bovine aortic endothelial cells (BAEC) | Bos taurus | - |
| additional information | treatment of BAEC cells with tumor necrosis factor-alpha supresses argininosuccinate synthase expression. reporter gene analysis demonstrates that TNF-alpha suppresses the AS proximal promoter and electrophoretic mobility shift assay shows reduced binding to three essential Sp1 elements | Bos taurus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| argininosuccinate synthase | - |
Bos taurus |
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Release 2023.1 (January 2023)
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