Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | inducible enzyme, immunostimulation of AS synthesis with lipopolysaccharide or cytokines, such as TNF-alpha, interleukin 1 and interferon-gamma | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | AS and GTP cyclohydrolase I are intimately associated with inflammatory arthritis, they may be important modulators of arthritis and may represent novel targets for modulation of disease activity | Mus musculus |
Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | involved in L-arginine synthesis from L-citrulline, urea cycle, rate-limiting enzyme for high output NO generation, inducible enzyme, AS synthesis is more strictly regulated at the posttranscriptional than the transcriptional level in vivo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
human tumor necrosis factor-alpha transgenic mice, 4 and 8 weeks old, and age-matched CBA x C57B1/6 wild-type controls | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | involved in L-arginine synthesis from L-citrulline, urea cycle, rate-limiting enzyme for high output NO generation, inducible enzyme, AS synthesis is more strictly regulated at the posttranscriptional than the transcriptional level in vivo | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Argininosuccinate synthetase | - |
Mus musculus |
AS | - |
Mus musculus |