Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | study of the effect of recombinant mycoplasma arginine deiminase on cell proliferation, good correlation of the resistance to this treatment with the AS activity in the cell lines | Homo sapiens | |
recombinant mycoplasma arginine deiminase | 350% increase in AS activity in HeLa cells after rADI treatment, no activity change in umbilical vein endothelial cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | study of the effect of recombinant mycoplasma arginine deiminase on cell proliferation, correlation of the low resistance to this treatment with a low AS activity in the sensitive cell line | Canis lupus familiaris | |
additional information | study of the effect of recombinant mycoplasma arginine deiminase on cell proliferation, good correlation of the high resistance to this treatment with a high AS activity in the cell line | Mus musculus | |
recombinant mycoplasma arginine deiminase | 36% decrease in AS activity after rADI treatment | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-citrulline + L-aspartate | Mus musculus | the rate-limiting enzyme for converting citrulline to arginine | AMP + diphosphate + L-argininosuccinate | - |
? | |
ATP + L-citrulline + L-aspartate | Homo sapiens | the rate-limiting enzyme for converting citrulline to arginine | AMP + diphosphate + L-argininosuccinate | - |
? | |
ATP + L-citrulline + L-aspartate | Canis lupus familiaris | the rate-limiting enzyme for converting citrulline to arginine | AMP + diphosphate + L-argininosuccinate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000001 | - |
37°C, cell homogenate | Canis lupus familiaris |
0.000006 | - |
37°C, A-549 cell homogenate | Homo sapiens |
0.000013 | - |
37°C, LNCaP cell homogenate | Homo sapiens |
0.000019 | - |
37°C, MCF-7 cell homogenate | Homo sapiens |
0.000048 | - |
37°C, HeLa cell homogenate | Homo sapiens |
0.000174 | - |
37°C, cell homogenate | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-citrulline + L-aspartate | catalyzes the coupling reaction between citrulline and arginine to form argininosuccinic acid | Mus musculus | AMP + diphosphate + L-argininosuccinate | - |
? | |
ATP + L-citrulline + L-aspartate | catalyzes the coupling reaction between citrulline and arginine to form argininosuccinic acid | Homo sapiens | AMP + diphosphate + L-argininosuccinate | - |
? | |
ATP + L-citrulline + L-aspartate | catalyzes the coupling reaction between citrulline and arginine to form argininosuccinic acid | Canis lupus familiaris | AMP + diphosphate + L-argininosuccinate | - |
? | |
ATP + L-citrulline + L-aspartate | the rate-limiting enzyme for converting citrulline to arginine | Mus musculus | AMP + diphosphate + L-argininosuccinate | - |
? | |
ATP + L-citrulline + L-aspartate | the rate-limiting enzyme for converting citrulline to arginine | Homo sapiens | AMP + diphosphate + L-argininosuccinate | - |
? | |
ATP + L-citrulline + L-aspartate | the rate-limiting enzyme for converting citrulline to arginine | Canis lupus familiaris | AMP + diphosphate + L-argininosuccinate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Argininosuccinate synthetase | - |
Mus musculus |
Argininosuccinate synthetase | - |
Homo sapiens |
Argininosuccinate synthetase | - |
Canis lupus familiaris |
AS | - |
Mus musculus |
AS | - |
Homo sapiens |
AS | - |
Canis lupus familiaris |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Canis lupus familiaris |