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Literature summary for 6.3.4.4 extracted from

  • Van der Weyden, M.B.; Kelly, W.N.
    Human adenylosuccinate synthetase. Partial purification, kinetic and regulatory properties of the enzyme from placenta (1974), J. Biol. Chem., 249, 7282-7289.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3',5'-cyclic GMP
-
Homo sapiens
6-mercaptopurine ribonucleotide
-
Homo sapiens
adenosine 3',5'-AMP
-
Homo sapiens
adenylosuccinate competitive with respect to IMP Homo sapiens
ADP
-
Homo sapiens
AMP competitive with respect to IMP Homo sapiens
CDP
-
Homo sapiens
CMP
-
Homo sapiens
dAMP
-
Homo sapiens
dCMP
-
Homo sapiens
dGDP
-
Homo sapiens
dGMP
-
Homo sapiens
GDP competitive with respect to GTP Homo sapiens
GMP competitive with respect to GTP Homo sapiens
IDP
-
Homo sapiens
succinate
-
Homo sapiens
TDP
-
Homo sapiens
TMP
-
Homo sapiens
UDP
-
Homo sapiens
UMP
-
Homo sapiens
XMP competitive with respect to IMP Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.031
-
GTP
-
Homo sapiens
0.037
-
IMP
-
Homo sapiens
0.95
-
Asp
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ can replace Mg2+ with lower efficiency Homo sapiens
Ca2+ can replace Mg2+ with lower efficiency Homo sapiens
Co2+ can replace Mg2+ with lower efficiency Homo sapiens
Mg2+ divalent cation required, maximal activity obtained with Mg2+ Homo sapiens
Mn2+ can replace Mg2+ with lower efficiency Homo sapiens
Ni2+ can replace Mg2+ with lower efficiency Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP sequential rapid equilibrium fully random mechanism Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00641
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + IMP + L-Asp
-
Homo sapiens GDP + phosphate + adenylosuccinate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7.4
-
Homo sapiens