Literature summary for 6.3.4.3 extracted from

Pike, S.T.; Rajendra, R.; Artzt, K.; Appling, D.R.
Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos (2010), J. Biol. Chem., 285, 4612-4620.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	MTHFD1L enzyme is present in mitochondria from normal embryonic tissues and embryonic fibroblast cell lines, and embryonic mitochondria possess the ability to synthesize formate from glycine. Greater than 75% of 1-C units entering the cytoplasmic methyl cycle are mitochondrially derived	Mus musculus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q3V3R1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	the MTHFD1L transcript is detected at all stages of mouse embryogenesis examined. MTHFD1L is expressed ubiquitously throughout the embryo but with localized regions of higher expression. The spatial pattern of MTHFD1L expression is virtually indistinguishable from that of MTHFD2 and cytoplasmic C1-THF synthase MTHFD1 in embryonic day 9.5 mouse embryos	Mus musculus	-
fibroblast	embryonic fibroblast cell line	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
MTHFD1L	-	Mus musculus

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Release 2023.1 (January 2023)