Cloned (Comment) | Organism |
---|---|
overexpression of FTL using the multicopy episomal vector pXNG4-FTL | Leishmania major |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazol[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioate | 5,10-formyltetrahydrofolate substrate analogue inhibits dehydrogenase activity | Leishmania major | |
2,4-diamino-6-(3,4-dichlorophenoxy)-quinazoline | - |
Leishmania major | |
2,4-diamino-6-benzyl-5-(3-phenylpropyl)-pyrimidine | - |
Leishmania major | |
methotrexate | - |
Leishmania major |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Leishmania major | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Leishmania major | Leishmania possess a second cytoplasmic pathway for 10-formyltetrahydrofolate synthesis through FTL | ? | - |
? | |
tetrahydrofolate + formate + ATP | Leishmania major | monofunctional enzyme | 10-formyltetrahydrofolate + ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Leishmania possess a second cytoplasmic pathway for 10-formyltetrahydrofolate synthesis through FTL | Leishmania major | ? | - |
? | |
tetrahydrofolate + formate + ATP | monofunctional enzyme | Leishmania major | 10-formyltetrahydrofolate + ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
formate-tetrahydrofolate ligase | - |
Leishmania major |
FTL | - |
Leishmania major |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
27 | - |
assay at | Leishmania major |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Leishmania major |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00004 | - |
dhch1-/pXNG4-FTL mutant, FV1 line | Leishmania major | methotrexate | |
0.00042 | - |
dhch1-/pXNG4-FTL mutant, FV1 line | Leishmania major | 2,4-diamino-6-benzyl-5-(3-phenylpropyl)-pyrimidine | |
0.00054 | - |
dhch1-/pXNG4-FTL mutant, FV1 line | Leishmania major | 2,4-diamino-6-(3,4-dichlorophenoxy)-quinazoline | |
0.0033 | - |
dhch1-/pXNG4-FTL mutant, FV1 line | Leishmania major | (2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazol[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioate | |
0.0037 | - |
WT/pXNG4-FTL mutant, FV1 line | Leishmania major | (2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazol[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioate |