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Literature summary for 6.3.4.3 extracted from

  • Murta, S.M.; Vickers, T.J.; Scott, D.A.; Beverley, S.M.
    Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major (2009), Mol. Microbiol., 71, 1386-1401.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of FTL using the multicopy episomal vector pXNG4-FTL Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazol[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioate 5,10-formyltetrahydrofolate substrate analogue inhibits dehydrogenase activity Leishmania major
2,4-diamino-6-(3,4-dichlorophenoxy)-quinazoline
-
Leishmania major
2,4-diamino-6-benzyl-5-(3-phenylpropyl)-pyrimidine
-
Leishmania major
methotrexate
-
Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Leishmania major 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Leishmania major Leishmania possess a second cytoplasmic pathway for 10-formyltetrahydrofolate synthesis through FTL ?
-
?
tetrahydrofolate + formate + ATP Leishmania major monofunctional enzyme 10-formyltetrahydrofolate + ADP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Leishmania possess a second cytoplasmic pathway for 10-formyltetrahydrofolate synthesis through FTL Leishmania major ?
-
?
tetrahydrofolate + formate + ATP monofunctional enzyme Leishmania major 10-formyltetrahydrofolate + ADP + phosphate
-
?

Synonyms

Synonyms Comment Organism
formate-tetrahydrofolate ligase
-
Leishmania major
FTL
-
Leishmania major

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
27
-
assay at Leishmania major

Cofactor

Cofactor Comment Organism Structure
ATP
-
Leishmania major

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00004
-
dhch1-/pXNG4-FTL mutant, FV1 line Leishmania major methotrexate
0.00042
-
dhch1-/pXNG4-FTL mutant, FV1 line Leishmania major 2,4-diamino-6-benzyl-5-(3-phenylpropyl)-pyrimidine
0.00054
-
dhch1-/pXNG4-FTL mutant, FV1 line Leishmania major 2,4-diamino-6-(3,4-dichlorophenoxy)-quinazoline
0.0033
-
dhch1-/pXNG4-FTL mutant, FV1 line Leishmania major (2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazol[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioate
0.0037
-
WT/pXNG4-FTL mutant, FV1 line Leishmania major (2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazol[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioate