Cloned (Comment) | Organism |
---|---|
expressed in CHO cells and Escherichia coli | Homo sapiens |
expressed in CHO cells and Escherichia coli | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the recombinant protein product (short isoform) of the alternatively spliced short transcript of the mitochondrial isozyme is not enzymatically active | Homo sapiens |
additional information | the recombinant protein product (short isoform) of the alternatively spliced short transcript of the mitochondrial isozyme is not enzymatically active | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | mitochondrial C1-THF synthase behaves as a peripheral membrane protein, tightly associated with the matrix side of the mitochondrial inner membrane | Homo sapiens | 5739 | - |
mitochondrion | mitochondrial C1-THF synthase behaves as a peripheral membrane protein, tightly associated with the matrix side of the mitochondrial inner membrane | Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
recombinant short isoform, SDS-PAGE | Homo sapiens |
107000 | - |
recombinant mitochondrial C1-THF synthase without the presequence but with the V5 epitope tag, SDS-PAGE | Homo sapiens |
107000 | - |
recombinant mitochondrial C1-THF synthase without the presequence but with the V5 epitope tag, SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
TALON cobalt metal affinity resin chromatography | Homo sapiens |
TALON cobalt metal affinity resin chromatography | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
spleen | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + formate + tetrahydrofolate | - |
Homo sapiens | ADP + phosphate + 10-formyltetrahydrofolate | - |
? | |
ATP + formate + tetrahydrofolate | - |
Rattus norvegicus | ADP + phosphate + 10-formyltetrahydrofolate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C(1)-tetrahydrofolate synthase | a monofunctional 10-formyl-tetrahydrofolate synthetase lacking the 5,10-methylene-tetrahydrofolate dehydrogenase and 5,10-methenyl-tetrahydrofolate cyclohydrolase activities typically found in the trifunctional cytoplasmic proteins | Homo sapiens |
C(1)-tetrahydrofolate synthase | a monofunctional 10-formyl-tetrahydrofolate synthetase lacking the 5,10-methylene-tetrahydrofolate dehydrogenase and 5,10-methenyl-tetrahydrofolate cyclohydrolase activities typically found in the trifunctional cytoplasmic proteins | Rattus norvegicus |
MTHFDIL | - |
Homo sapiens |
MTHFDIL | - |
Rattus norvegicus |
THF synthase | - |
Homo sapiens |
THF synthase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |