Literature summary for 6.3.4.3 extracted from

Hum, D.W.; MacKenzie, R.E.
Expression of active domains of a human folate-dependent trifunctional enzyme in Escherichia coli (1991), Protein Eng., 4, 493-500.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli, localization of the interdomain region of the trifunctional enzyme by site-directed mutagenesis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	trifunctional enzyme with 10-formyltetrahydrofolate synthetase, EC 6.3.4.3, 5,10-methenyltetrahydrofolate cyclohydrolase, EC 3.5.4.9, and 5,10-methylenetetrahydrofolate dehydrogenase activity, EC 1.5.1.5	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + formate + tetrahydrofolate	-	Homo sapiens	ADP + phosphate + 10-formyltetrahydrofolate	-	?

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Release 2023.1 (January 2023)