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Literature summary for 6.3.4.3 extracted from

  • Shoaf, W.T.; Neece, S.H.; Ljungdahl, L.G.
    Effects of temperature and ammonium ions on formyltetrahydrofolate synthetase from Clostridium thermoaceticum (1974), Biochim. Biophys. Acta, 334, 448-458.
No PubMed abstract available
Search for more literature for 6.3.4.3

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km-values for the forward reaction as a function of temperature in the presence and absence of NH4Cl Moorella thermoacetica

Metals/Ions

Metals/Ions Comment Organism Structure
NH4+ activates forward and reverse reaction Moorella thermoacetica
Rb+ activates synthesis of 10-formyltetrahydrofolate Moorella thermoacetica

Organism

Organism UniProt Comment Textmining
Moorella thermoacetica
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + formate + tetrahydrofolate r Moorella thermoacetica ADP + phosphate + 10-formyltetrahydrofolate
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 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
 NH4+ and K+, but not Na+ increase the thermostability Moorella thermoacetica
70
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 rapid inactivation in absence of NH4Cl. In presence of 50 mM NH4Cl, about 50% loss of activity after 15 min and no more loss of activity thereafter Moorella thermoacetica