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Literature summary for 6.3.4.25 extracted from

  • Sleiman, D.; Garcia, P.; Lagune, M.; Loch, J.; Haouz, A.; Taib, N.; Roethlisberger, P.; Gribaldo, S.; Marliere, P.; Kaminski, P.
    A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes (2021), Science, 372, 516-520 .
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
structure of apo-PurZ at 1.3 A resolution and structures in complex with ATP, with dGMP, ATP, and Mg2+, and with beta,gamma-methyleneadenosine 5'-triphosphate, dGMP, and aspartate Vibrio phage phiVC8

Organism

Organism UniProt Comment Textmining
cyanophage S-2L
-
-
-
Vibrio phage phiVC8 G3FFN6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + dGMP + L-aspartate
-
Vibrio phage phiVC8 ADP + phosphate + 2-amino-2'-deoxy-N6-[(2S)-succino]adenylate
-
?
ATP + dGMP + L-aspartate
-
cyanophage S-2L ADP + phosphate + 2-amino-2'-deoxy-N6-[(2S)-succino]adenylate
-
?

Synonyms

Synonyms Comment Organism
Adenylosuccinate synthetase
-
Vibrio phage phiVC8
phiVC8_p27
-
Vibrio phage phiVC8
purZ
-
Vibrio phage phiVC8

General Information

General Information Comment Organism
physiological function cyanophage S-2L and Vibrio phage PhiVC8 encode a third purine pathway catalyzed by PurZ. PurZ condenses aspartate with deoxyguanylate into dSMP (N6-succino-2-amino-2'-deoxyadenylate), which undergoes defumarylation and phosphorylation to give dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate), a substrate for the phage DNA polymerase Vibrio phage phiVC8
physiological function cyanophage S-2L and Vibrio phage PhiVC8 encode a third purine pathway catalyzed by PurZ. PurZ condenses aspartate with deoxyguanylate into dSMP (N6-succino-2-amino-2'-deoxyadenylate), which undergoes defumarylation and phosphorylation to give dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate), a substrate for the phage DNA polymerase cyanophage S-2L