Literature summary for 6.3.4.21 extracted from

Piacente, F.; Caffa, I.; Ravera, S.; Sociali, G.; Passalacqua, M.; Vellone, V.G.; Becherini, P.; Reverberi, D.; Monacelli, F.; Ballestrero, A.; Odetti, P.; Cagnetta, A.; Cea, M.; Nahimana, A.; Duchosal, M.; Bruzzone, S.; Nencioni, A.
Nicotinic acid phosphoribosyltransferase regulates cancer cell metabolism, susceptibility to NAMPT inhibitors, and DNA repair (2017), Cancer Res., 77, 3857-3869 .

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Application

Application	Comment	Organism
medicine	NAPRT is amplified and overexpressed in a subset of common types of cancer, including ovarian cancer, where NAPRT expression correlates with a BRCAness gene expression signature. Both NAPRT and nicotinamide phosphoribosyltransferase NAMPT increase intracellular NAD+ levels. NAPRT silencing reduces energy status, protein synthesis, and cell size in ovarian and pancreatic cancer cells. NAPRT silencing sensitizes cells to NAMPT inhibitors both in vitro and in vivo. Reducing NAPRT levels in a BRCA2-deficient cancer cell line exacerbates DNA damage in response to chemotherapeutics	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2-hydroxynicotinic acid	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q6XQN6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CAPAN-1 cell	-	Homo sapiens	-
fetal cell line	Phoenix cell	Homo sapiens	-
HEK-293T cell	-	Homo sapiens	-
MiaPaCa-2 cell	-	Homo sapiens	-
OVCAR-4 cell	-	Homo sapiens	-
OVCAR-5 cell	-	Homo sapiens	-
OVCAR-8 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
NAPRT	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	both NAPRT and nicotinamide phosphoribosyltransferase NAMPT increase intracellular NAD+ levels. NAPRT silencing reduces energy status, protein synthesis, and cell size in ovarian and pancreatic cancer cells. NAPRT silencing sensitizes cells to NAMPT inhibitors both in vitro and in vivo	Homo sapiens

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Release 2023.1 (January 2023)