Protein Variants | Comment | Organism |
---|---|---|
C404G | inactive | Saccharomyces cerevisiae |
D70A | mutation in the ATP binding site, mutant exhibits approximately twofold increase in the number of cells containing filaments | Saccharomyces cerevisiae |
E146A | mutation in the ATP binding site, mutant exhibits approximately twofold increase in the number of cells containing filaments | Saccharomyces cerevisiae |
E161K | mutation in CTP binding site, filament formation is completely disrupted and the enzyme can only form foci. Mutation decreases the affinity of the enzyme for CTP | Saccharomyces cerevisiae |
R381M | mutation in L11 lid, 3.1fold increase in the number of cells forming filaments | Saccharomyces cerevisiae |
R381P | mutation in L11 lid, 3.1fold increase in the number of cells forming filaments | Saccharomyces cerevisiae |
S36A | mutation in phosphorylation site, causes an approximately twofold decrease in the frequency of filament formation | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P28274 | - |
- |
Saccharomyces cerevisiae ATCC 204508 | P28274 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
CTP synthase 1 | - |
Saccharomyces cerevisiae |
URA7 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | destabilization of the active tetrameric form of the enzyme increases filament formation. The sites responsible for feedback inhibition and allosteric activation control filament length, implying that multiple regions of the enzyme can influence filament structure. Blocking catalysis without disrupting the regulatory sites of the enzyme does not affect filament formation or length | Saccharomyces cerevisiae |