A20R |
mutation disrupts cytoophidium assembly |
Drosophila melanogaster |
DELTA20 |
deletion of the N-terminal 20 amino acids alone is sufficient to disrupt cytoophidium assembly, mutant protein forms distinct cytoplasmic structures which appear as large clusters |
Drosophila melanogaster |
K2E |
mutation disrupts cytoophidium assembly |
Drosophila melanogaster |
additional information |
in cytoophidium assembly, formation of heteromeric CTP synthase filaments takes place, which is disrupted by CTP synthase carrying a mutated N-terminal alanine residue. N-terminal swapping, i.e. exchange of the 20 N-terminal amino acids to the residues of human and yeast CTP synthase does not affect CTPsyn cytoophidium assembly |
Drosophila melanogaster |
Y3E |
mutation disrupts cytoophidium assembly |
Drosophila melanogaster |