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Literature summary for 6.3.4.16 extracted from

  • Takakusa, H.; Mohar, I.; Kavanagh, T.J.; Kelly, E.J.; Kaspera, R.; Nelson, S.D.
    Protein tyrosine nitration of mitochondrial carbamoyl phosphate synthetase 1 and its functional consequences (2012), Biochem. Biophys. Res. Commun., 420, 54-60.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.4.16

Activating Compound

Activating Compound Comment Organism Structure
N-acetyl-L-glutamate nitration at Y1450 in an alpha-helix of allosteric domain prevents activation of CPS1 by N-acetyl-L-glutamate Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
peroxynitrite CPS1 activity is decreased by treatment with peroxynitrite in a peroxynitrite concentration- and time-dependent manner due to tyrosine nitration (47% decrease in 1 min and 60% decrease in 10 min with 1 mM peroxynitrite) Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NH4+ + HCO3- + H2O Mus musculus
-
 ADP + phosphate + carbamoyl phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8C196
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NH4+ + HCO3- + H2O
-
 Mus musculus ADP + phosphate + carbamoyl phosphate
-
 ?

Synonyms

Synonyms Comment Organism
carbamoyl phosphate synthetase 1
-
 Mus musculus
CPS1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus