BRENDA - Enzyme Database show
show all sequences of 6.3.4.16

Human carbamoyl-phosphate synthetase: insight into N-acetylglutamate interaction and the functional effects of a common single nucleotide polymorphism

Ahuja, V.; Powers-Lee, S.G.; J. Inherit. Metab. Dis. 31, 481-491 (2008)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
N-acetylglutamate
the enzyme requires allosteric activation by N-acetylglutamate
Homo sapiens
Cloned(Commentary)
Commentary
Organism
gene CPSI, DNA and amino acid sequence determination and analysis, expression of the N-terminally His6-FLAG-tagged enzyme and mutant T1406D in Schizosaccharomyces pombe from pESP5, expression of mature protein of 1462 amino acid residues with the first 39 amino acids of the precursor protein replaced by a methionyl residue
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
additional information
connstruction of a domain A deleted mutant hCPS_DELTAA and functional characterization, the mutant shows slightly inccreased catalytic efficiency in absence of N-acetylglutamate and a 4fold increased Km for N-acetylglutamate compared to the wild-type enzyme
Homo sapiens
T1406D
naturally occurring single nucleotide polymorphism, phenotype, overview
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics, the Km of the enzyme for ammonia is 100fold lower than that for CPSs that also use glutamine, EC 6.3.5.5, kinetics for bicarbonate-dependent ATPase and carbamoyl phosphate-dependent ATP synthesis reactions, overview
Homo sapiens
0.29
-
N-acetylglutamate
pH 7.6, 37°C, wild-type enzyme
Homo sapiens
0.35
-
NH4+
pH 7.6, 37°C, wild-type enzyme
Homo sapiens
0.44
-
N-acetylglutamate
pH 7.6, 37°C, mutant T1406D
Homo sapiens
0.55
-
ATP
pH 7.6, 37°C, wild-type enzyme
Homo sapiens
0.58
-
NH4+
pH 7.6, 37°C, mutant T1406D
Homo sapiens
0.68
-
ATP
pH 7.6, 37°C, mutant T1406D
Homo sapiens
2.44
-
HCO3-
pH 7.6, 37°C, wild-type enzyme
Homo sapiens
2.49
-
HCO3-
pH 7.6, 37°C, mutant T1406D
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrial matrix
the N-terminal targeting signal normally directs the nuclear-encoded protein to the mitochondrial matrix and is cleaved as the protein enters the matrix
Homo sapiens
5759
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + NH4+ + HCO3- + H2O
Homo sapiens
the human enzyme removes excess, potentially neurotoxic ammonia via the urea cycle in a tightly regulated manner that avoids depletion of the ammonia pool, and shows inability to use glutamine as an alternative nitrogen donor
ADP + phosphate + carbamoyl phosphate
-
-
?
additional information
Homo sapiens
severe hyperammonaemia and high mortality are observed in hCPS deficiency, a rare autosomal disease
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P31327
gene CPSI
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
small intestine
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 ATP + NH3 + CO2 + H2O
-
693489
Homo sapiens
2 ADP + phosphate + carbamoyl phosphate
-
-
-
-
ATP + NH4+ + HCO3- + H2O
-
693489
Homo sapiens
ADP + phosphate + carbamoyl phosphate
-
-
-
?
ATP + NH4+ + HCO3- + H2O
the human enzyme removes excess, potentially neurotoxic ammonia via the urea cycle in a tightly regulated manner that avoids depletion of the ammonia pool, and shows inability to use glutamine as an alternative nitrogen donor
693489
Homo sapiens
ADP + phosphate + carbamoyl phosphate
-
-
-
?
additional information
severe hyperammonaemia and high mortality are observed in hCPS deficiency, a rare autosomal disease
693489
Homo sapiens
?
-
-
-
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
5.54
-
NH3
pH 7.6, 37°C, mutant T1406D
Homo sapiens
5.73
-
NH3
pH 7.6, 37°C, wild-type enzyme
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6
-
assay at
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
N-acetylglutamate
the enzyme requires allosteric activation by N-acetylglutamate
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
gene CPSI, DNA and amino acid sequence determination and analysis, expression of the N-terminally His6-FLAG-tagged enzyme and mutant T1406D in Schizosaccharomyces pombe from pESP5, expression of mature protein of 1462 amino acid residues with the first 39 amino acids of the precursor protein replaced by a methionyl residue
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
connstruction of a domain A deleted mutant hCPS_DELTAA and functional characterization, the mutant shows slightly inccreased catalytic efficiency in absence of N-acetylglutamate and a 4fold increased Km for N-acetylglutamate compared to the wild-type enzyme
Homo sapiens
T1406D
naturally occurring single nucleotide polymorphism, phenotype, overview
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics, the Km of the enzyme for ammonia is 100fold lower than that for CPSs that also use glutamine, EC 6.3.5.5, kinetics for bicarbonate-dependent ATPase and carbamoyl phosphate-dependent ATP synthesis reactions, overview
Homo sapiens
0.29
-
N-acetylglutamate
pH 7.6, 37°C, wild-type enzyme
Homo sapiens
0.35
-
NH4+
pH 7.6, 37°C, wild-type enzyme
Homo sapiens
0.44
-
N-acetylglutamate
pH 7.6, 37°C, mutant T1406D
Homo sapiens
0.55
-
ATP
pH 7.6, 37°C, wild-type enzyme
Homo sapiens
0.58
-
NH4+
pH 7.6, 37°C, mutant T1406D
Homo sapiens
0.68
-
ATP
pH 7.6, 37°C, mutant T1406D
Homo sapiens
2.44
-
HCO3-
pH 7.6, 37°C, wild-type enzyme
Homo sapiens
2.49
-
HCO3-
pH 7.6, 37°C, mutant T1406D
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrial matrix
the N-terminal targeting signal normally directs the nuclear-encoded protein to the mitochondrial matrix and is cleaved as the protein enters the matrix
Homo sapiens
5759
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + NH4+ + HCO3- + H2O
Homo sapiens
the human enzyme removes excess, potentially neurotoxic ammonia via the urea cycle in a tightly regulated manner that avoids depletion of the ammonia pool, and shows inability to use glutamine as an alternative nitrogen donor
ADP + phosphate + carbamoyl phosphate
-
-
?
additional information
Homo sapiens
severe hyperammonaemia and high mortality are observed in hCPS deficiency, a rare autosomal disease
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
small intestine
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 ATP + NH3 + CO2 + H2O
-
693489
Homo sapiens
2 ADP + phosphate + carbamoyl phosphate
-
-
-
-
ATP + NH4+ + HCO3- + H2O
-
693489
Homo sapiens
ADP + phosphate + carbamoyl phosphate
-
-
-
?
ATP + NH4+ + HCO3- + H2O
the human enzyme removes excess, potentially neurotoxic ammonia via the urea cycle in a tightly regulated manner that avoids depletion of the ammonia pool, and shows inability to use glutamine as an alternative nitrogen donor
693489
Homo sapiens
ADP + phosphate + carbamoyl phosphate
-
-
-
?
additional information
severe hyperammonaemia and high mortality are observed in hCPS deficiency, a rare autosomal disease
693489
Homo sapiens
?
-
-
-
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
5.54
-
NH3
pH 7.6, 37°C, mutant T1406D
Homo sapiens
5.73
-
NH3
pH 7.6, 37°C, wild-type enzyme
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6
-
assay at
Homo sapiens
Other publictions for EC 6.3.4.16
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
727610
Diez-Fernandez
Molecular characterization of ...
Homo sapiens
Hum. Mutat.
34
1149-1159
2013
3
-
1
-
11
-
1
19
1
-
2
1
-
2
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
3
-
1
1
-
11
-
-
1
-
19
1
-
2
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
726867
Takakusa
Protein tyrosine nitration of ...
Mus musculus
Biochem. Biophys. Res. Commun.
420
54-60
2012
1
-
-
-
-
-
1
-
1
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
726868
Lopes-Marques
Human carbamoyl phosphate synt ...
Homo sapiens
Biochem. Biophys. Res. Commun.
421
409-412
2012
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
728044
Ip
Hepatic carbamoyl phosphate sy ...
Litoria caerulea
J. Comp. Physiol. B
182
1081-1094
2012
-
-
-
-
-
-
-
-
1
-
1
1
-
5
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
728172
Popa
The smallest active carbamoyl ...
Methanobrevibacter smithii
J. Mol. Microbiol. Biotechnol.
22
287-299
2012
-
-
1
-
-
-
-
3
-
-
3
1
-
5
-
-
1
-
-
5
2
-
1
1
-
-
-
3
-
-
-
1
-
1
-
-
-
1
1
-
-
-
-
-
-
3
-
-
3
1
-
-
-
1
-
5
2
-
1
1
-
-
-
3
-
-
-
1
-
-
-
-
3
3
713715
Liu
DNA methylation suppresses exp ...
Homo sapiens
Am. J. Pathol.
178
652-661
2011
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
715151
Haeberle
Molecular defects in human car ...
Homo sapiens
Hum. Mutat.
32
579-589
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
702101
Ogura
Overexpression of SIRT5 confir ...
Mus musculus, Mus musculus C57BL/6
Biochem. Biophys. Res. Commun.
393
73-78
2010
1
-
-
-
1
-
-
-
1
1
-
2
-
143
-
1
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
1
-
2
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
702142
Pekkala
Structural insight on the cont ...
Escherichia coli, Homo sapiens, Rattus norvegicus
Biochem. J.
424
211-220
2009
5
-
1
-
6
-
-
-
2
3
-
3
-
6
-
-
1
-
-
1
-
-
3
-
3
-
-
-
3
-
-
3
-
-
-
5
-
1
3
-
6
-
-
-
-
-
2
3
-
3
-
-
-
1
-
1
-
-
3
-
3
-
-
-
3
-
-
-
-
4
4
-
-
-
702953
Ono
A case of carbamoyl phosphate ...
Homo sapiens
Brain Dev.
31
779-781
2009
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703149
Nakagawa
SIRT5 deacetylates carbamoyl p ...
Mus musculus
Cell
137
560-570
2009
2
-
-
-
-
-
-
-
1
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
703281
Klaus
Highly variable clinical pheno ...
Homo sapiens
Clin. Genet.
76
263-269
2009
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705524
Kostiuk
Non-radioactive detection of p ...
Rattus norvegicus
Methods Enzymol.
457
149-165
2009
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706078
Moore
Genetic variants of GSNOR and ...
Homo sapiens
Pediatr. Pulmonol.
44
649-654
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
691725
Poyck
Expression of glutamine synthe ...
Sus scrofa
Cells Tissues Organs
188
259-269
2008
-
1
-
-
-
-
-
-
1
1
-
1
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693247
Hart
Role of Cys1327 and Cys1337 in ...
Homo sapiens
J. Biol. Chem.
284
5977-5985
2008
1
-
1
-
2
-
-
1
1
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693489
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Human carbamoyl-phosphate synt ...
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2008
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693935
Butler
The antigen for Hep Par 1 anti ...
Homo sapiens
Lab. Invest.
88
78-88
2008
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1
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672452
Schoneveld
cyclicAMP and glucocorticoid r ...
Rattus norvegicus
Biochimie
89
574-580
2007
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1
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673597
Hoogenkamp
Hepatocyte-specific interplay ...
Rattus norvegicus
FEBS J.
274
37-45
2007
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674389
Kim
Rat liver 10-formyltetrahydrof ...
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604-609
2007
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675160
Lindley
Sequence, expression and evolu ...
Xenopus laevis
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2007
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675859
Canter
Genetic variation in the mitoc ...
Homo sapiens
Mitochondrion
7
204-210
2007
1
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672441
Hoogenkamp
In vivo footprinting of the ca ...
Rattus norvegicus
Biochimie
88
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2006
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673178
Crouser
Carbamoyl phosphate synthase-1 ...
Mus musculus
Crit. Care Med.
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662070
Huo
Molecular cloning, identificat ...
Homo sapiens
J. Biochem. Mol. Biol.
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2005
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651464
Summar
Relationship between carbamoyl ...
Homo sapiens
Hypertension
43
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2004
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662548
Wright
The crab-eating frog,Rana canc ...
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J. Exp. Zool. A
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662880
Summar
Environmentally determined gen ...
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Mol. Genet. Metab.
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652418
Saeed-Kothe
Gain of glutaminase function i ...
Homo sapiens, Rana catesbeiana, Rattus norvegicus
J. Biol. Chem.
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2003
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652334
Eroglu
Unmasking a functional alloste ...
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Saeed-Kothe
Specificity determining residu ...
Rana catesbeiana
J. Biol. Chem.
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7231-7238
2002
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651213
Purcarea
Cloning, expression, and struc ...
Pyrococcus abyssi
Extremophiles
5
229-239
2001
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Corvi
Regulation of mitochondrial ca ...
Rattus norvegicus
J. Biol. Chem.
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2001
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2
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642229
Ramon-Maiques
The 1.5 A resolution crystal s ...
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J. Mol. Biol.
299
463-476
2000
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3
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Davis
Comparison of total body urea ...
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Uriarte
The carbamoyl-phosphate synthe ...
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Saha
-
Types of carbamyl phosphate sy ...
Clarias batrachus, Heteropneustes fossilis
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1999
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Durbecq
The carbamate kinase-like carb ...
Pyrococcus furiosus
Proc. Natl. Acad. Sci. USA
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1997
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Purification and characterizat ...
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Alonso
Oxidative inactivation of carb ...
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Influence of anions on the act ...
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A structure-reactivity study o ...
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The apparent Km of ammonia for ...
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Smith
Distribution of glutamine synt ...
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Proc. Natl. Acad. Sci. USA
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1988
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1474
Alonso
Carbamoyl-phosphate synthase i ...
Phycomyces blakesleeanus
Biochim. Biophys. Acta
955
175-186
1988
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Lund
Inhibition of carbamoyl-phosph ...
Rattus norvegicus
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1987
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Alonso
Inactivation of mitochondrial ...
Rattus norvegicus
Arch. Biochem. Biophys.
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1987
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Powers-Lee
The interaction of rat liver c ...
Rattus norvegicus
J. Biol. Chem.
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1987
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1460
Cerdan
Role of calcium as an inhibito ...
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1984
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Guadalajara
Inactivation of carbamoyl phos ...
Frog, Mesocricetus auratus, Rattus norvegicus
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1983
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1452
Lof
Properties of carbamoyl-phosph ...
Rattus norvegicus
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1983
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1453
McIntyre
Isolation of an immunologicall ...
Rattus norvegicus
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1981
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1454
Meijer
Inhibition by Ca2+ of carbamoy ...
Rattus norvegicus
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256
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1981
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1461
Lusty
Catalytically active monomer a ...
Rattus norvegicus
Biochemistry
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3665-3675
1981
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1462
Britton
Synthesis of carbamoyl phospha ...
Rattus norvegicus
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1981
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1463
Rubio
Carbamoyl phosphate synthetase ...
Homo sapiens
Biochim. Biophys. Acta
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150-160
1981
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Cohen
The apparent Km of ATPMg for c ...
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Pierson
Human carbamylphosphate synthe ...
Homo sapiens
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Mori
Preparation of crystalline car ...
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Lusty
Carbamyl phosphate synthetase. ...
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Lusty
Carbamoylphosphate synthetase ...
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Raijman
Purification, composition, and ...
Rattus norvegicus
Arch. Biochem. Biophys.
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270-278
1976
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1
1
1
1
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Clarke
A major polypeptide component ...
Rattus norvegicus
J. Biol. Chem.
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1976
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Elliott
Purification and characterisat ...
Bos taurus
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1973
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Tatibana
Two carbamyl phosphate synthet ...
Mammalia, Mus musculus, Rattus norvegicus
Adv. Enzyme Regul.
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1972
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