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Literature summary for 6.3.4.16 extracted from

  • Corvi, M.M.; Soltys, C.L.; Berthiaume, L.G.
    Regulation of mitochondrial carbamoyl-phosphate synthetase 1 activity by active site fatty acylation (2001), J. Biol. Chem., 276, 45704-45712.
    View publication on PubMed
Search for more literature for 6.3.4.16

Inhibitors

Inhibitors Comment Organism Structure
palmitoyl-CoA irreversible inactivation in a time- and concentration-dependent manner, this fatty acylation is specific for long-chain fatty acyl-CoA Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
165000
-
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NH3 + CO2 + H2O Rattus norvegicus the first and rate-limiting step of the urea synthesis ADP + phosphate + carbamoyl phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.3 0.46
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NH3 + CO2 + H2O
-
 Rattus norvegicus ADP + phosphate + carbamoyl phosphate
-
 ?
ATP + NH3 + CO2 + H2O the first and rate-limiting step of the urea synthesis Rattus norvegicus ADP + phosphate + carbamoyl phosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.015
-
 palmitoyl-CoA pH 7.6, 25°C, substrate: MgATP2- Rattus norvegicus
0.018
-
 palmitoyl-CoA pH 7.6, 25°C, substrate: ammonia Rattus norvegicus
0.024
-
 palmitoyl-CoA pH 7.6, 25°C, substrate: HCO3- Rattus norvegicus