Literature summary for 6.3.4.15 extracted from

Feng, Y.; Chin, C.; Chakravartty, V.; Gao, R.; Crispell, E.; Weiss, D.; Cronan, J.
The atypical occurrence of two biotin protein ligases in Francisella novicida is due to distinct roles in virulence and biotin metabolism (2015), mBio, 6, e00591 .

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Organism

Organism	UniProt	Comment	Textmining
Francisella tularensis subsp. novicida	-	-	-

Synonyms

Synonyms	Comment	Organism
BirA	-	Francisella tularensis subsp. novicida

General Information

General Information	Comment	Organism
physiological function	Francisella novicida encodes two biotin protein ligases. BirA and BplA are both functional biotin protein ligases. BirA has a ligase domain as well as an N-terminal DNA-binding regulatory domain. BirA, but not BplA, regulates transcription of the biotin synthetic operon, regulating and thereby likely preventing wasteful synthesis of biotin. Isoform BplA lacks the N-terminal DNA binding motif and is more efficient in ligase reaction than BirA. Expression of BplA (but not birA) increases significantly during infection of macrophages. BplA (but not BirA) is required for bacterial replication within macrophages as well as in mice	Francisella tularensis subsp. novicida

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Release 2023.1 (January 2023)