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Literature summary for 6.3.4.13 extracted from

  • Nierlich, D.P.
    Phosphoribosylglycinamide synthetase from Aerobacter aerogenes (1978), Methods Enzymol., 51, 179-185.
    View publication on PubMed
Search for more literature for 6.3.4.13

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
 Klebsiella aerogenes
EDTA
-
 Klebsiella aerogenes
NaF
-
 Klebsiella aerogenes
PCMB
-
 Klebsiella aerogenes

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.056
-
 ATP at a Mg2+ concentration of 5.7 mM Klebsiella aerogenes
0.19
-
 Gly
-
 Klebsiella aerogenes

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Klebsiella aerogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-phosphoribosylamine + Gly Klebsiella aerogenes second step in de novo path of purine biosynthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Klebsiella aerogenes
-
 i.e. Klebsiella pneumoniae
-

Purification (Commentary)

Purification (Comment) Organism
-
 Klebsiella aerogenes

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.7
-
-
 Klebsiella aerogenes

Storage Stability

Storage Stability Organism
-18°C, stable for at least 1 year Klebsiella aerogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-phosphoribosylamine + Gly
-
 Klebsiella aerogenes ADP + phosphate + 5-phosphoribosylglycinamide
-
 ?
ATP + 5-phosphoribosylamine + Gly second step in de novo path of purine biosynthesis Klebsiella aerogenes ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8
-
 Klebsiella aerogenes