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Literature summary for 6.3.4.13 extracted from

  • Cheng, Y.S.; Murray, M.; Schendel, F.; Otvos, J.; Wehrli, S.; Stubbe, J.
    Chemical characterization of phosphoribosylamine, a substrate for newly discovered trifunctional protein containing glycinamide ribonucleotide synthetase activity (1987), Adv. Enzyme Regul., 26, 319-333.
    View publication on PubMed
Search for more literature for 6.3.4.13

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.13
-
 5'-phosphoribosylglycinamide
-
 Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 x * 40000 Schizosaccharomyces pombe
45000
-
 x * 45000 Drosophila melanogaster
47000
-
 x * 47000 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-phosphoribosylamine + Gly Gallus gallus enzyme of the de novo purine biosynthetic pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Escherichia coli
-
-
-
Gallus gallus
-
 trifunctional enzyme with phosphoribosylamine-glycine ligase activity, glycinamide ribonucleotide transformylase activity, and aminoimidazole ribonucleotide synthetase activity
-
Schizosaccharomyces pombe
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.2
-
-
 Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-phospho-D-ribosylamine + Gly
-
 Gallus gallus ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide
-
 ?
ATP + 5-phosphoribosylamine + Gly
-
 Drosophila melanogaster ADP + phosphate + 5-phosphoribosylglycinamide
-
 ?
ATP + 5-phosphoribosylamine + Gly
-
 Schizosaccharomyces pombe ADP + phosphate + 5-phosphoribosylglycinamide
-
 ?
ATP + 5-phosphoribosylamine + Gly r Gallus gallus ADP + phosphate + 5-phosphoribosylglycinamide
-
 ?
ATP + 5-phosphoribosylamine + Gly r Escherichia coli ADP + phosphate + 5-phosphoribosylglycinamide
-
 ?
ATP + 5-phosphoribosylamine + Gly enzyme of the de novo purine biosynthetic pathway Gallus gallus ?
-
 ?

Subunits

Subunits Comment Organism
?
-
 Gallus gallus
? x * 40000 Schizosaccharomyces pombe
? x * 45000 Drosophila melanogaster
? x * 47000 Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Gallus gallus