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Literature summary for 6.3.4.10 extracted from

  • Bao, B.; Pestinger, V.; Hassan, Y.; Borgstahl, G.; Kolar, C.; Zempleni, J.
    Holocarboxylase synthetase is a chromatin protein and interacts directly with histone H3 to mediate biotinylation of K9 and K18 (2011), J. Nutr. Biochem., 22, 470-475.
    View publication on PubMed
Search for more literature for 6.3.4.10

Cloned(Commentary)

Cloned (Comment) Organism
expression of HCS and HCS-green fluorescent protein fusion protein in HEK-293 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information HCS co-localizes with histone H3 in human cells with physical interactions between HCS and H3. The N-terminal and C-terminal domains in HCS participate in H3 binding Homo sapiens
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + biotin + histone H3.2
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 Homo sapiens AMP + diphosphate + biotin-histone H3.2
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 ?
ATP + biotin + histone H3.2
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 Homo sapiens AMP + diphosphate + biotin-histone H3.2 biotinylation of residues K9 and K18 in histone H3 ?
ATP + biotin + histone H3.2 N-terminal amino acids 1-25
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 Homo sapiens AMP + diphosphate + biotin-histone H3.2 N-terminal amino acids 1-25 biotinylation of residues K9 and K18 ?

General Information

General Information Comment Organism
physiological function HCS co-localizes with histone H3 in human cells with physical interactions between HCS and H3. The N-terminal and C-terminal domains in HCS participate in H3 binding Homo sapiens