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Literature summary for 6.3.3.5 extracted from

  • Matoba, Y.; Uda, N.; Kudo, M.; Sugiyama, M.
    Cyclization mechanism catalyzed by an ATP-grasp enzyme essential for D-cycloserine biosynthesis (2020), FEBS J., 287, 2763-2778.
    View publication on PubMed
Search for more literature for 6.3.3.5

Crystallization (Commentary)

Crystallization (Comment) Organism
structure of DcsG in a complex with ADP and Mg2+ Streptomyces lavendulae

Protein Variants

Protein Variants Comment Organism
C142A mutation reduces the activity of the three substrates investigated by 25% to 60% Streptomyces lavendulae
E271A mutation reduces the activity of the three substrates investigated by more than 95% Streptomyces lavendulae
E271Q mutation reduces the activity of the three substrates investigated by more than 95% Streptomyces lavendulae
K202A mutation reduces the activity of the three substrates investigated by more than 95% Streptomyces lavendulae
P215A mutation reduces the activity of the three substrates investigated by about 90% Streptomyces lavendulae
R220A mutation reduces the activity of the three substrates investigated by about 90% Streptomyces lavendulae
R254A mutation reduces the activity of the three substrates investigated by more than 95% Streptomyces lavendulae
S276A mutation reduces the activity of the three substrates investigated by 50 to 90% Streptomyces lavendulae
W57A mutation reduces the activity of the three substrates investigated by more than 95% Streptomyces lavendulae
Y143A mutation reduces the activity of the three substrates investigated by 70 to 95% Streptomyces lavendulae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O-ureido-D-serine + ATP + H2O Streptomyces lavendulae
-
 D-cycloserine + CO2 + NH3 + ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces lavendulae D2Z030 ATP-grasp superfamily enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-ureido-D-serine + ATP + H2O
-
 Streptomyces lavendulae D-cycloserine + CO2 + NH3 + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
DcsG
-
 Streptomyces lavendulae

General Information

General Information Comment Organism
physiological function DcsG catalyzes specifically the generation of an intramolecular covalent bond Streptomyces lavendulae