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Literature summary for 6.3.2.9 extracted from

  • Tanner, M.E.; Vaganay, S.; van Heijenoort, J.; Blanot, D.
    Phosphinate inhibitors of the D-glutamic acid-adding enzyme of peptidoglycan biosynthesis (1996), J. Org. Chem., 61, 1756-1760.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
[1-[(6-Uridinediphospho)hexanamido]ethyl](2,4-dicarboxybutyl)phosphinate pentasodium salt good inhibitor, closely resembles the tetrahedral intermediate that is presumed to form the ligation reaction Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + UDP-N-acetylmuramoyl-L-Ala + Glu Escherichia coli key role in peptidoglycan biosynthesis ?
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
JM83(pMLD58), overproducing strain
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UDP-N-acetylmuramoyl-L-Ala + Glu
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
?
ATP + UDP-N-acetylmuramoyl-L-Ala + Glu key role in peptidoglycan biosynthesis Escherichia coli ?
-
?