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Literature summary for 6.3.2.7 extracted from

  • Strancar, K.; Boniface, A.; Blanot, D.; Gobec, S.
    Phosphinate inhibitors of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase (MurE) (2007), Arch. Pharm., 340, 127-134.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-([hydroxy[1-([N-[(4-nitrobenzyl)sulfonyl]-D-alanyl]amino)ethyl]phosphoryl]methyl)pentanedioic acid 1 mM, 13% residual activity Staphylococcus aureus
2-[[(1-[[(2E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]amino]ethyl)(hydroxy)phosphoryl]methyl]pentanedioic acid 1 mM, 52% residual activity Staphylococcus aureus
2-[[(1-[[(benzyloxy)carbonyl]amino]ethyl)(hydroxy)phosphoryl]methyl]pentanedioic acid 1 mM, 35% residual activity Staphylococcus aureus
2-[[hydroxy(1-[[(2E)-3-(3-hydroxyphenyl)prop-2-enoyl]amino]ethyl)phosphoryl]methyl]pentanedioic acid 1 mM, 21% residual activity Staphylococcus aureus
2-[[hydroxy(1-[[(2E)-3-phenylprop-2-enoyl]amino]ethyl)phosphoryl]methyl]pentanedioic acid 1 mM, 50% residual activity Staphylococcus aureus
2-[[hydroxy(1-[[(3-nitrobenzyl)sulfonyl]amino]ethyl)phosphoryl]methyl]pentanedioic acid 1 mM, 52% residual activity Staphylococcus aureus
2-[[hydroxy(1-[[(3-nitrophenyl)sulfonyl]amino]ethyl)phosphoryl]methyl]pentanedioic acid 1 mM, 39% residual activity Staphylococcus aureus
2-[[hydroxy(1-[[(4-nitrobenzyl)sulfonyl]amino]ethyl)phosphoryl]methyl]pentanedioic acid 1 mM, 44% residual activity Staphylococcus aureus
2-[[hydroxy(2-methyl-1-[[(3-nitrobenzyl)sulfonyl]-amino]butyl)phosphoryl]methyl]pentanedioic acid 1 mM, 71% residual activity Staphylococcus aureus
2-[[hydroxy(2-methyl-1-[[(4-nitrobenzyl)sulfonyl]-amino]butyl)phosphoryl]methyl] pentanedioic acid 1 mM, 54% residual activity Staphylococcus aureus
2-[[hydroxy(2-methyl-1-[[(4-nitrobenzyl)sulfonyl]amino]propyl)phosphoryl]methyl] pentanedioic acid 1 mM, 29% residual activity Staphylococcus aureus
2-[[[1-[(1,3-benzodioxol-5-ylacetyl)amino]ethyl](hydroxy)phosphoryl]methyl]pentanedioic acid 1 mM, 12% residual activity; 1 mM, 42% residual activity; 1 mM, 60% residual activity Staphylococcus aureus
3-[(1-[[(benzyloxy)carbonyl]amino]ethyl)(hydroxy)phosphoryl]propanoic acid 1 mM, 50% residual activity Staphylococcus aureus
3-[hydroxy[1-([N-[(4-nitrobenzyl)sulfonyl]-D-alanyl]amino)ethyl]phosphoryl]propanoic acid 1 mM, 46% residual activity Staphylococcus aureus
3-[[1-[(1,3-benzodioxol-5-ylacetyl)amino]ethyl](hydroxy)phosphoryl]propanoic acid 1 mM, 35% residual activity Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu + L-Lys
-
Staphylococcus aureus ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys
-
?

Synonyms

Synonyms Comment Organism
MurE
-
Staphylococcus aureus
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase
-
Staphylococcus aureus