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Literature summary for 6.3.2.61 extracted from

  • Devambez, I.; van Dijk, J.; Benlefki, S.; Layalle, S.; Grau, Y.; Rogowski, K.; Parmentier, M.L.; Soustelle, L.
    Identification of DmTTLL5 as a major tubulin glutamylase in the Drosophila nervous system (2017), Sci. Rep., 7, 16254 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
n ATP + [tubulin]-L-glutamate + n L-glutamate Drosophila melanogaster overall reaction, the enzyme initiates microtubule glutamylation specifically on alpha-tubulin [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Drosophila melanogaster
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nervous system
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 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
n ATP + [tubulin]-L-glutamate + n L-glutamate overall reaction, the enzyme initiates microtubule glutamylation specifically on alpha-tubulin Drosophila melanogaster [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
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 ?

Synonyms

Synonyms Comment Organism
alpha-tubulin glutamylase
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 Drosophila melanogaster
CG31108
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 Drosophila melanogaster
TTLL5
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 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction isoform TTLL5 mutant flies are viable without any defect in vesicular axonal transport, synapse morphology and larval locomotion. Moreover, isoform TTLL5 mutant flies display normal negative geotaxis behavior and their lifespan is not altered Drosophila melanogaster
physiological function isoform TTLL5 is the major enzyme responsible for initiating neuronal mictotubule glutamylation specifically on alpha-tubulin Drosophila melanogaster