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Literature summary for 6.3.2.61 extracted from

  • Ikegami, K.; Sato, S.; Nakamura, K.; Ostrowski, L.; Setou, M.
    Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry (2010), Proc. Natl. Acad. Sci. USA, 107, 10490-10495 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
n ATP + [tubulin]-L-glutamate + n L-glutamate Mus musculus overall reaction, the enzyme has an initiating activity with a preference for alpha-tubulin, but also shows partial activity on beta-tubulin [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
n ATP + [tubulin]-L-glutamate + n L-glutamate overall reaction, the enzyme has an initiating activity with a preference for alpha-tubulin, but also shows partial activity on beta-tubulin Mus musculus [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
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 ?

Synonyms

Synonyms Comment Organism
TTLL1
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 Mus musculus
tubulin tyrosine ligase-like protein 1
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 Mus musculus

General Information

General Information Comment Organism
malfunction along with the loss of axonemal curvature, the axonemes and tracheal epithelial cilia from enzyme knockout mice lose beating asymmetry which results in a reduction of cilia-generated fluid flow in trachea from the knockout mice. The mice display a significant accumulation of mucus in the nasal cavity, and also emit frequent coughing- or sneezing-like noises Mus musculus
physiological function enzyme-mediated ubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry Mus musculus