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Literature summary for 6.3.2.61 extracted from

  • Westermann, S.; Plessmann, U.; Weber, K.
    Synthetic peptides identify the minimal substrate requirements of tubulin polyglutamylase in side chain elongation (1999), FEBS Lett., 459, 90-94 .
    View publication on PubMed
Search for more literature for 6.3.2.61

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
n ATP + [tubulin]-L-glutamate + n L-glutamate Crithidia fasciculata overall reaction, up to 70 mol of L-glutamate is incorporated per alphabeta-heterodimer [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
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Organism

Organism UniProt Comment Textmining
Crithidia fasciculata
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information synthetic peptides related to the carboxyterminal end of brain alpha- and beta-tubulin are subject to polyglutamylation if they display a free alpha-carboxylate group of a glutamic acid residue Crithidia fasciculata ?
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n ATP + [tubulin]-L-glutamate + n L-glutamate overall reaction, up to 70 mol of L-glutamate is incorporated per alphabeta-heterodimer Crithidia fasciculata [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
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 ?

Synonyms

Synonyms Comment Organism
tubulin polyglutamylase
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 Crithidia fasciculata